Journal
EUROSURVEILLANCE
Volume 21, Issue 7, Pages 15-31Publisher
EUR CENTRE DIS PREVENTION & CONTROL
DOI: 10.2807/1560-7917.ES.2016.21.7.30139
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- WHO-EURO
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Influenza A(H3N2), A(H1N1)pdm09 and B viruses co-circulated in Europe in 2014/15. We undertook a multicentre case-control study in eight European countries to measure 2014/15 influenza vaccine effectiveness (VE) against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza. General practitioners swabbed all or a systematic sample of ILI patients. We compared the odds of vaccination of ILI influenza positive patients to negative patients. We calculated adjusted VE by influenza type/subtype, and age group. Among 6,579 ILI patients included, 1,828 were A(H3N2), 539 A(H1N1) pdm09 and 1,038 B. VE against A(H3N2) was 14.4% (95% confidence interval (CI): -6.3 to 31.0) overall, 20.7% (95% CI: -22.3 to 48.5), 10.9% (95% CI -30.8 to 39.3) and 15.8% (95% CI: -20.2 to 41.0) among those aged 0-14, 15-59 and >= 60 years, respectively. VE against A(H1N1) pdm09 was 54.2% (95% CI: 31.2 to 69.6) overall, 73.1% (95% CI: 39.6 to 88.1), 59.7% (95% CI: 10.9 to 81.8), and 22.4% (95% CI: -44.4 to 58.4) among those aged 0-14, 15-59 and >= 60 years respectively. VE against B was 48.0% (95% CI: 28.9 to 61.9) overall, 62.1% (95% CI: 14.9 to 83.1), 41.4% (95% CI: 6.2 to 63.4) and 50.4% (95% CI: 14.6 to 71.2) among those aged 0-14, 15-59 and = 60 years respectively. VE against A (H1N1) pdm09 and B was moderate. The low VE against A (H3N2) is consistent with the reported mismatch between circulating and vaccine strains.
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