Influenza vaccine effectiveness in adults 65 years and older, Denmark, 2015/16-a rapid epidemiological and virological assessment

In Denmark, both influenza A(H1N1) pdm09 and influenza B co-circulated in the 2015/ 16 season. We estimated the vaccine effectiveness (VE) of the trivalent influenza vaccine in patients 65 years and older using the test-negative case-control design. The adjusted VE against influenza A(H1N1) pdm09 was 35.0% (95% confidence interval (CI): 11.1-52.4) and against influenza B 4.1% (95% CI:-22.0 to 24.7). The majority of influenza A(H1N1) pdm09 circulating in 2015/ 16 belonged to the new genetic subgroup subclade 6B.1.