4.6 Article

CCM2-deficient endothelial cells undergo a ROCK-dependent reprogramming into senescence-associated secretory phenotype

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

Aileen A. Ren et al.

Summary: Vascular malformations are caused by increased signaling through the PI3K-mTOR pathway and loss of function of the CCM complex, which are found in the majority of human CCMs. Using mouse models, researchers discovered that the formation of CCMs can be effectively blocked by the mTORC1 inhibitor rapamycin.

NATURE (2021)

Article Genetics & Heredity

Postzygotic mosaicism in cerebral cavernous malformation

Matthias Rath et al.

JOURNAL OF MEDICAL GENETICS (2020)

Article Biochemistry & Molecular Biology

UBTD1 is a mechano-regulator controlling cancer aggressiveness

Stephanie Torrino et al.

EMBO REPORTS (2019)

Article Multidisciplinary Sciences

L1 drives IFN in senescent cells and promotes age-associated inflammation

Marco De Cecco et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Low fluid shear stress conditions contribute to activation of cerebral cavernous malformation signalling pathways

Jia Li et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Review Clinical Neurology

Cavernous angiomas: deconstructing a neurosurgical disease

Issam A. Awad et al.

JOURNAL OF NEUROSURGERY (2019)

Article Biochemistry & Molecular Biology

Transcriptome signature of cellular senescence

Gabriel Casella et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Multidisciplinary Sciences

Endothelial cell clonal expansion in the development of cerebral cavernous malformations

Matteo Malinyerno et al.

NATURE COMMUNICATIONS (2019)

Article Developmental Biology

Cellular senescence in development, regeneration and disease

Muriel Rhinn et al.

DEVELOPMENT (2019)

Review Medicine, Research & Experimental

Targeting senescent cells in translational medicine

Marta Paez-Ribes et al.

EMBO MOLECULAR MEDICINE (2019)

Review Medicine, Research & Experimental

Autophagy, Cellular Aging and Age-related Human Diseases

So Yeong Cheon et al.

EXPERIMENTAL NEUROBIOLOGY (2019)

Review Oncology

Unmasking senescence: context-dependent effects of SASP in cancer

Douglas V. Faget et al.

NATURE REVIEWS CANCER (2019)

Review Biochemistry & Molecular Biology

NADPH Oxidases and Mitochondria in Vascular Senescence

Gloria Salazar

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Cardiac & Cardiovascular Systems

Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells

Matthew R. Detter et al.

CIRCULATION RESEARCH (2018)

Article Clinical Neurology

Co-expression of tissue factor and IL-6 in immature endothelial cells of cerebral cavernous malformations

Shouhei Noshiro et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2017)

Review Cardiac & Cardiovascular Systems

Toll-like receptor-4 signaling pathway in aorta aging and diseases: its double nature

Carmela Rita Balistreri et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2017)

Article Multidisciplinary Sciences

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

Alan T. Tang et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Unmasking Transcriptional Heterogeneity in Senescent Cells

Alejandra Hernandez-Segura et al.

CURRENT BIOLOGY (2017)

Article Medicine, Research & Experimental

KLF4 is a key determinant in the development and progression of cerebral cavernous malformations

Roberto Cuttano et al.

EMBO MOLECULAR MEDICINE (2016)

Review Cell Biology

Biomarkers to identify and isolate senescent cells

Mantas Matjusaitis et al.

AGEING RESEARCH REVIEWS (2016)

Review Biochemistry & Molecular Biology

Framework to function: mechanosensitive regulators of gene transcription

Megan Finch-Edmondson et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2016)

Article Cell Biology

Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins

Marc Renz et al.

DEVELOPMENTAL CELL (2015)

Article Medicine, Research & Experimental

Defective autophagy is a key feature of cerebral cavernous malformations

Saverio Marchi et al.

EMBO MOLECULAR MEDICINE (2015)

Article Multidisciplinary Sciences

3D niche microarrays for systems-level analyses of cell fate

A. Ranga et al.

NATURE COMMUNICATIONS (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Review Physiology

Aging, Cellular Senescence, and Cancer

Judith Campisi

ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)

Article Multidisciplinary Sciences

EndMT contributes to the onset and progression of cerebral cavernous malformations

Luigi Maddaluno et al.

NATURE (2013)

Article Genetics & Heredity

CCM3 Mutations Are Associated with Early-Onset Cerebral Hemorrhage and Multiple Meningiomas

F. Riant et al.

MOLECULAR SYNDROMOLOGY (2013)

Article Biochemistry & Molecular Biology

A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease

David A. McDonald et al.

HUMAN MOLECULAR GENETICS (2011)

Article Medicine, Research & Experimental

Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice

Aubrey C. Chan et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Review Pathology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Jean -Philippe Coppe et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

Article Biochemistry & Molecular Biology

Rho Kinase Inhibition Rescues the Endothelial Cell Cerebral Cavernous Malformation Phenotype

Asya L. Borikova et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Cell Biology

CCM1 regulates vascular-lumen organization by inducing endothelial polarity

Maria Grazia Lampugnani et al.

JOURNAL OF CELL SCIENCE (2010)

Article Immunology

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

Rebecca A. Stockton et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

Article Multidisciplinary Sciences

KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species

Luca Goitre et al.

PLOS ONE (2010)

Article Biochemistry & Molecular Biology

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

Kevin J. Whitehead et al.

NATURE MEDICINE (2009)

Article Clinical Neurology

Immune Response in Human Cerebral Cavernous Malformations

Changbin Shi et al.

STROKE (2009)

Article Cell Biology

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell-cell junctions

Angela Glading et al.

JOURNAL OF CELL BIOLOGY (2007)

Review Clinical Neurology

Genetics of cavernous angiomas

Pierre Labouge et al.

LANCET NEUROLOGY (2007)

Article Biochemistry & Molecular Biology

Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase

Toru Tanaka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis

JS Zawistowski et al.

HUMAN MOLECULAR GENETICS (2005)

Article Immunology

KLF2 is a novel transcriptional regulator of endothelial proinflammatory activation

S SenBanerjee et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

Article Multidisciplinary Sciences

Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics

MP Lutolf et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Letter Cell Biology

Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock

MT Uhlik et al.

NATURE CELL BIOLOGY (2003)

Article Multidisciplinary Sciences

Mitotic misregulation and human aging

DH Ly et al.

SCIENCE (2000)