4.8 Article

Enantio- and Regioselective Palladium(II)-Catalyzed Dioxygenation of (Aza-)Alkenols

Journal

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 40, Pages 21723-21727

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202109312

Keywords

alkene difunctionalizations; alkenols; dioxygenation; enantioselectivity; hypervalent iodine; Pd catalysis

Funding

  1. Universita degli Studi di Milano
  2. Politecnico di Milano within the CRUI-CARE Agreement

Ask authors/readers for more resources

Excellent enantio- and diastereoselectivity can be achieved in the oxidative Pd-catalyzed dioxygenation of (aza-)alkenols by using specific chiral ligands and hypervalent-iodine compounds.
An oxidative Pd-catalyzed intra-intermolecular dioxygenation of (aza-)alkenols has been reported, with total regioselectivity. To study the stereoselectivity, different chiral ligands as well as different hypervalent-iodine compounds have been compared. In particular, by using a C-6 modified pyridinyl-oxazoline (Pyox) ligand and hypervalent iodine bearing an aromatic ring, an excellent enantio- and diastereoselectivity has been achieved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available