Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 47, Pages 25089-25096Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202110888
Keywords
artificial skin; helical microfibers; materials science; microfluidic spinning; solvent effects
Categories
Funding
- National Natural Science Foundation of China [21736006]
- National Key Research and Development Program of China [2018YFC1602800]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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A new method for producing helical microfibers is proposed using a phase inversion process, capable of efficiently manufacturing strong, stretchable, flexible, and biocompatible fibers. These fibers can be used to fabricate bi-oriented stretchable artificial abdominal skin, preventing hernia formation and promoting wound healing. This research offers a universal approach to design helical microfibers and provides new insights into artificial skin.
Microfluidic spinning technology (MST), incorporating microfluidics with chemical reactions, has gained considerable interest for constructing anisotropic advanced microfibers, especially helical microfibers. However, these efforts suffer from the limited material choices, restricting their applications. Here, a new phase inversion-based microfluidic spinning (PIMS) method is proposed for producing helical microfibers. This method undergoes a physicochemical phase inversion process, which is capable of efficiently manufacturing strong (tensile stress of more than 25 MPa), stretchable, flexible and biocompatible helical microfibers. The helical microfibers can be used to fabricate bi-oriented stretchable artificial abdominal skin, preventing incisional hernia formation and promoting the wound healing without conglutination. This research not only offers a universal approach to design helical microfibers but also provides a new insight into artificial skin.
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