Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 39, Pages 21231-21236Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202108534
Keywords
azaborine; carboboration; C-boron enolates; enyne; palladium
Categories
Funding
- National Institute of General Medical Sciences of the National Institutes of Health [R01GM136920]
- Excellence Initiative of Universitde Pau et des Pays de lAdour I-Site E2S UPPA
- Boston College start-up funds
Ask authors/readers for more resources
This study introduces a new family of carbon-bound boron enolates produced by kinetically controlled halogen exchange between chlorocatecholborane and silylketene acetals. These C-boron enolates are shown to activate 1,3-enyne substrates in a carboboration reaction when catalyzed by a Pd-0/Senphos ligand complex. The described cis-carboboration reaction leads to highly substituted dienyl boron building blocks with excellent site-, regio-, and diastereoselectivity.
A new family of carbon-bound boron enolates, generated by a kinetically controlled halogen exchange between chlorocatecholborane and silylketene acetals, is described. These C-boron enolates are demonstrated to activate 1,3-enyne substrates in the presence of a Pd-0/Senphos ligand complex, resulting in the first examples of a carboboration reaction of an alkyne with enolate-equivalent nucleophiles. Highly substituted dienyl boron building blocks are produced in excellent site-, regio-, and diastereoselectivity by the described catalytic cis-carboboration reaction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available