Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 33, Pages 18122-18128Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202103969
Keywords
block copolymers; compartmentalization; intramolecular cross-linking; Janus-shaped single-chain nanoparticles; microphase separation
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Funding
- MEXT [26888001, 15K17862, 19H02769]
- Photoexcitonix Project of Hokkaido University
- Creative Research Institute of Hokkaido University
- JSPS Fellowship for Young Scientists
- Grants-in-Aid for Scientific Research [15K17862, 26888001] Funding Source: KAKEN
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Developing an efficient and versatile process to transform a single linear polymer chain into a shape-defined nanoobject is a major challenge in the fields of chemistry and nanotechnology. In this study, one-shot intrablock cross-linking of linear block copolymers was used to create single-chain nanoparticles (SCNPs) with two chemically compartmentalized domains (Janus-shaped SCNP). The Janus-shaped SCNP exhibited similar compactly folded conformation and compartmentalized block localization to natural proteins' self-folded tertiary structures, demonstrating the versatility of the one-shot intrablock cross-linking method.
Developing an efficient and versatile process to transform a single linear polymer chain into a shape-defined nanoobject is a major challenge in the fields of chemistry and nanotechnology to replicate sophisticated biological functions of proteins and nucleic acids in a synthetic polymer system. In this study, we performed one-shot intrablock cross-linking of linear block copolymers (BCPs) to realize single-chain nanoparticles (SCNPs) with two chemically compartmentalized domains (Janus-shaped SCNPs). Detailed structural characterizations of the Janus-shaped SCNP composed of polystyrene-block-poly(glycolic acid) revealed its compactly folded conformation and compartmentalized block localization, similar to the self-folded tertiary structures of natural proteins. Versatility of the one-shot intrablock cross-linking was demonstrated using several different BCP precursors. In addition, the Janus-shaped SCNP produce miniscule microphase-separated structures.
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