Enantioselective Addition of Pyrazoles to Dienes**

We report the first enantioselective addition of pyrazoles to 1,3-dienes. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: a Pd-0-catalyzed ligand-to-ligand hydrogen transfer (LLHT). This hydroamination tolerates a range of functional groups and advances the field of diene hydrofunctionalization.

Automated summary

This study presents the first enantioselective addition of pyrazoles to 1,3-dienes, resulting in the formation of secondary and tertiary allylic pyrazoles with excellent regioselectivity. Mechanistic studies indicate a distinct pathway involving Pd-0-catalyzed ligand-to-ligand hydrogen transfer (LLHT), expanding the field of diene hydrofunctionalization with tolerance for various functional groups.