Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 36, Pages 19648-19652Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202105297
Keywords
chiral detection; D-amino acid; energy transfer; lanthanide-doped nanoparticles; near-infrared light
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Funding
- National Natural Science Foundation of China [61805153, 61705137, 21775049]
- Science and Technology Project of Shenzhen [JCYJ20170817093821657, KQJSCX20180328093614762]
- China Postdoctoral Science Foundation [2018M643174]
- Singapore Ministry of Education [MOE2017-T2-2-110]
- National Research Foundation
- Prime Minister's Office of Singapore under its NRF Competitive Research Programme [NRF-CRP23-2019-0070]
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Detection of DAAs is crucial for understanding metabolic processes and managing related diseases. Current detection strategies are limited, but a new enzyme-coupled nanoprobe offers a versatile platform for noninvasive detection with high enantioselectivity.
D-amino acids (DAAs) are indispensable in regulating diverse metabolic pathways. Selective and sensitive detection of DAAs is crucial for understanding the complexity of metabolic processes and managing associated diseases. However, current DAA detection strategies mainly rely on bulky instrumentation or electrochemical probes, limiting their cellular and animal applications. Here we report an enzyme-coupled nanoprobe that can detect enantiospecific DAAs through synergistic energy transfer. This nanoprobe offers near-infrared upconversion capability, a wide dynamic detection range, and a detection limit of 2.2 mu M, providing a versatile platform for in vivo noninvasive detection of DAAs with high enantioselectivity. These results potentially allow real-time monitoring of biomolecular handedness in living animals, as well as developing antipsychotic treatment strategies.
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