Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 37, Pages 20452-20460Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202107155
Keywords
abscess; antibiofilm; bacterial infection; nitric oxide; self-reporting release
Categories
Funding
- National Key R&D Program of China [2020YFA0710700]
- National Natural Scientific Foundation of China (NNSFC) [51690150, 51690154, 52073270, 51722307, 22073090]
- Fundamental Research Funds for the Central Universities [WK2060190102]
Ask authors/readers for more resources
This study introduces a coumarin-based NO donor that can be activated under red-light conditions, enabling self-reporting NO release through photoredox catalysis. This NO-releasing platform shows promise in eradicating bacterial biofilms and treating cutaneous abscesses.
Nitric oxide (NO) serves as a key regulator of many physiological processes and as a potent therapeutic agent. The local delivery of NO is important to achieve target therapeutic outcomes due to the toxicity of NO at high concentrations. Although light stimulus represents a non-invasive tool with spatiotemporal precision to mediate NO release, many photoresponsive NO-releasing molecules can only respond to ultraviolet (UV) or near-UV visible light with low penetration and high phototoxicity. We report that coumarin-based NO donors with maximal absorbances at 328 nm can be activated under (deep) red-light (630 or 700 nm) irradiation in the presence of palladium(II) tetraphenyltetrabenzoporphyrin, enabling stoichiometric and self-reporting NO release with a photolysis quantum yield of 8 % via photoredox catalysis. This NO-releasing platform with ciprofloxacin loading can eradicate Pseudomonas aeruginosa biofilm in vitro and treat cutaneous abscesses in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available