Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 41, Pages 22505-22512Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202109518
Keywords
antibacterial agents; antibiofilm agents; biofilms; crystal violet; dynamic constitutional chemistry
Categories
Funding
- Ministry of Research and Innovation, CNCS-UEFISCDI [PN-III-P3-3.6-H2020-2016-0011]
- UNamur FSR PhD grant
Ask authors/readers for more resources
Dynamic constitutional frameworks (DCFs) composed of trialdehyde core, diamine PEG connector, and various neutral, anionic, or cationic heads demonstrated effective biofilm inhibition or disruption. Among them, polycationic DCFs showed the best antibiofilm activity, with the nature of cationic heads playing a significant role. DCF3B exhibited the best antibiofilm activity, while DCF3C, with a guanidinium functional head, was superior in inhibiting biofilm growth in an advanced in vitro biofilm model of chronic wound infection.
Dynamic constitutional frameworks (DCFs) were synthesized and screened for biofilm inhibition or disruption. They are composed of a trialdehyde core reversibly linked to a diamine PEG connector and to a variety of neutral, anionic, or cationic heads, to generate a library of DCFs to generate multivalent dendritic architectures in the presence of Pseudomonas aeruginosa and Staphylococcus aureus. The best DCFs were always polycationic and the nature of the cationic heads significantly impact the antibiofilm activity. The best antibiofilm activity was observed for DCF3B, displaying a polyethyleneimine head. A simple inactive guanidinium functional head strongly inhibited biofilm growth when assayed as a multivalent DCF3C. Using a more advanced in vitro biofilm model of chronic wound infection, DCF3C was found significantly superior than all other DCFs. These results demonstrate the versatility and effectiveness of DCFs as low cost and efficient systems for antibiofilm disruption.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available