Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 47, Pages 24844-24848Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202109771
Keywords
asymmetric Catellani annulation; C-H activation; chiral amines; cooperative catalysis; palladium
Categories
Funding
- NSFC [21831007]
- Fundamental Research Funds for the Central Universities [WK2060190083]
Ask authors/readers for more resources
The chiral indoline-2-carboxylic acid enables a highly enantioselective Catellani-type annulation, directly assembling a diverse range of chiral all-carbon bridged ring systems with high levels of stereochemical control through coordinating orientation to the arylpalladium(II) center identified by control experiments and DFT calculations.
Chiral indoline-2-carboxylic acid has been identified to enable a highly enantioselective Catellani-type annulation of (hetero)aryl, alkenyl triflate and conjugated vinyl iodides with 4-(bromomethyl)cyclohexanone, directly assembling a diverse range of chiral all-carbon bridged ring systems. Control experiments and DFT calculations suggest that the coordinating orientation of the chiral amino acid to the arylpalladium(II) center allows for high levels of stereochemical control.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available