Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 37, Pages 20243-20248Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202106603
Keywords
chiral polymer; fractional crystallization; noncovalent interaction; stereoseparation; tailor-made inhibitor
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Funding
- National Natural Science Foundation of China [51833001, 51674002, 51921002, 21905003]
- China Postdoctoral Science Foundation [2019M660002, 2020T130011]
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A strategy using commercially available achiral polymers as platforms and attaching various chiral small molecules as recognition side-chains through non-covalent interactions was reported. This method was used to selectively crystallize seven racemates in different solvents, showing good stereoselectivity.
Stereoselective inhibition of the nucleation and crystal growth of one enantiomer aided by tailor-made polymeric additives is an efficient method to obtain enantiopure compounds. However, the conventional preparation of polymeric additives from chiral monomers are laborious and limited in structures, which impedes their rapid optimization and applicability. Herein, we report a plug-and-play strategy to facilitate synthesis by using commercially available achiral polymers as the platform to attach various chiral small molecules as the recognition side-chains through non-covalent interactions. A library of supramolecular polymers made up of two vinyl polymers and six small molecules were applied with seeds in the selective crystallization of seven racemates in different solvents. They showed good to excellent stereoselectivity in yielding crystals with high enantiomeric purities in conglomerates and racemic compound forming systems. This convenient, low-cost modular synthesis strategy of polymeric additives will allow for high-efficient, economical resolution of various racemates on different scales.
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