Efficient Asymmetric Biomimetic Aldol Reaction of Glycinates and Trifluoromethyl Ketones by Carbonyl Catalysis

The direct asymmetric aldol reaction of glycinates represents an intriguing and straightforward strategy to make biologically significant chiral beta-hydroxy-alpha-amino-acid derivatives. But it is not easy to realize the transformation due to the disruption of the reactive NH2 group of glycinates. Inspired by the enzymatic aldol reaction of glycine, we successfully developed an asymmetric aldol reaction of glycinate 5 and trifluoromethyl ketones 4 with 0.1-0.0033 mol % of chiral N-methyl pyridoxal 7 a as the catalyst, producing chiral beta-trifluoromethyl-beta-hydroxy-alpha-amino-acid esters 6 in 55-82 % yields (for the syn-diastereomers) with up to >20:1 dr and 99 % ee under very mild conditions. The reaction proceeds via a catalytic cycle similar to the enzymatic aldol reaction of glycine. Pyridoxal catalyst 7 a activates both reactants at the same time and brings them together in a specific spatial orientation, accounting for the high efficiency as well as excellent diastereo- and enantioselectivities.

Automated summary

The direct asymmetric aldol reaction of glycinates has been achieved by using chiral N-methyl pyridoxal as the catalyst, leading to high yields of chiral beta-trifluoromethyl-beta-hydroxy-alpha-amino-acid esters with excellent stereoselectivity and enantioselectivity.