Journal
ANALYTICAL CHEMISTRY
Volume 93, Issue 27, Pages 9621-9627Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.1c01787
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Funding
- National Natural Science Foundation of China [21575115, 22001193]
- Program for Chang Jiang Scholars and Innovative Research Team, Ministry of Education, China [IRT-16R61]
- Program of Tianjin Science and Technology Major Project and Engineering [19ZXYXSY00090]
- Special Fund Project for the central government to guide local science and technology development (2020)
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The combination of manganese dioxide nanosheets and cysteine-assisted emitting manganese dioxide nanospheres has been fabricated for fluorescence detection of glutathione. The system achieved wide response range and superior specificity, showing potential in the field of biomedicine.
Manganese dioxide nanosheets combined with cysteine-assisted emitting manganese dioxide nanospheres (Cys-MnO2 nanospheres) is fabricated for the first time as an off-on fluorescence detection platform for glutathione (GSH). In this sensing system, Cys-MnO2 nanospheres served as energy donors, while MnO2 nanosheets were used as both energy acceptors and recognition units. MnO2 nanosheets can effectively quench the fluorescence of Cys-MnO2 nanospheres through the fluorescence resonance energy transfer (FRET). The addition of GSH could reduce MnO2 nanosheets into Mn2+, disrupting the FRET process and restoring the fluorescence of Cys-MnO2 nanospheres. Under the optimum conditions, the switch-on platform we established has a wide response to GSH with a range of 5-50 mu M and 150-800 mu M, as well as a superior specificity. Importantly, all components of the sensor are nontoxic, biocompatible, easily prepared, and have a high utilization of raw materials. Moreover, the sensing system achieved satisfactory results in human serum, showing a tremendous potential in the field of biomedicine.
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