Journal
ANALYTICAL CHEMISTRY
Volume 93, Issue 23, Pages 8265-8272Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.1c01104
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Funding
- Israel Scientific Foundation (ISF) [810/18]
- Center for Absorption in Science of the Ministry of Immigrant Absorption of Israel under the KAMEA program
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In this study, a dual-dye ratiometric system was utilized for quantification monitoring of anticancer drug delivery and release in tumors, demonstrating its advantages in a mouse model.
Fluorescent dyes linked to drug delivery systems provide important real-time information on the efficacy of drug delivery. However, the quantitative monitoring of drug distribution is challenging because of interferences from the biological sample and instrumental setup. To improve quantification of anticancer drug delivery followed by drug release in tumor, we equipped an antibody-drug conjugate (ADC) with a turn-on near-infrared (NIR) dye, sensitive to drug release, and a reference NIR dye. In this study, chlorambucil (CLB) was chosen as a model anticancer drug and Trastuzumab monoclonal antibody specific to Her2 receptors overexpressed in many tumors was taken as the carrier. The advantage of the obtained dual-dye ratiometric system for drug release monitoring was demonstrated in mice model.
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