Comparison of the Dynamic Thermal Gradient to Temperature-Programmed Conditions in Gas Chromatography Using a Stochastic Transport Model

Article Chemistry, Analytical

Simulating Capillary Gas Chromatographic Separations including Thermal Gradient Conditions

H. Dennis Tolley et al.

Summary: This study introduces a method for simulating molecular transport in capillary gas chromatography, which has been experimentally validated. The model provides reasonable predictions for isothermal, temperature-programmed, and thermal gradient GC separations. The relatively low errors in simulated peak elution time and width demonstrate the model's ability to reflect transport processes and predict meaningful outcomes for GC separations.

ANALYTICAL CHEMISTRY (2021)

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Article Biochemical Research Methods

Simulation of the effects of negative thermal gradients on separation performance of gas chromatography

Jan Leppert et al.

Summary: The study investigates the effect of a gradient of solute velocity on the chromatographic separation of closely spaced solutes using simulation. Results show that the addition of a negative velocity gradient cannot improve separation, but can increase resolution in specific cases. In practical applications, adding a negative velocity gradient can be beneficial for the separation of broadly injected solutes.

JOURNAL OF CHROMATOGRAPHY A (2021)

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Article Chemistry, Analytical

Comparison of Static Thermal Gradient to Isothermal Conditions in Gas Chromatography Using a Stochastic Transport Model

Samuel Avila et al.

Summary: This paper compares static thermal gradient gas chromatography to isothermal GC using a stochastic transport model to simulate peak characteristics for C12-C14 hydrocarbons. The simulations show that a linear thermal gradient improves resolution significantly, while a static, non-linear thermal gradient provides the largest observed gains in resolution. Optimized linear thermal gradient conditions are shown to improve resolution by as much as 8.8% over comparative isothermal conditions.

ANALYTICAL CHEMISTRY (2021)

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Article Biochemical Research Methods