Journal
ANALYTICAL CHEMISTRY
Volume 93, Issue 26, Pages 9244-9249Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.1c01511
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21775091, 91753111, 21927811]
- Key Research and Development Program of Shandong Province [2018YFJH0502]
Ask authors/readers for more resources
The study highlights the importance of mitochondrial viscosity in diseases, and introduces a newly designed fluorescent probe for real-time imaging and analysis. Results show that H2O2 can increase mitochondrial viscosity, while heavy metal ions decrease it, providing valuable insights into mitochondrial functions and related diseases.
As an important cell organelle, the mitochondrion has special viscosities, while abnormal mitochondrial viscosity is closely related to many diseases. Hydrogen peroxide (H2O2) is an active molecule related to the cell microenvironment, and its influence on mitochondrial viscosity is still not clear, so further investigation is needed. In addition, since excessive accumulation of heavy metal ions would lead to cells' dysfunction, the study of effect of excessive heavy metal ions on mitochondrial viscosity has not been reported. Herein, we designed and synthesized a mitochondrial-targeting near-infrared fluorescent probe (Mito-NV) for real-time in situ imaging and analysis of mitochondrial viscosity. Furthermore, the probe revealed that H2O2 can raise mitochondrial viscosity, while heavy metal ions reduce the viscosity. This work is of great significance for understanding the execution of mitochondrial functions and the occurrence and development of related diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available