Journal
ANALYTICAL CHEMISTRY
Volume 93, Issue 30, Pages 10593-10600Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.1c01798
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Funding
- National Key Research and Development Program of China [2018YFB1105400, 2019YFA0802800]
- National Natural Science Foundation of China [21472090]
- Natural Science Foundation of Jiangsu Province [BK20180334]
- Fundamental Research Funds for Central Universities of the Nanjing University
- Scientific Research Foundation of the Graduate School of the Nanjing University [2018CL12]
- Key Research and Development Program of the Jiangsu Provincial Department of Science and Technology of China [BE2019002]
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The study developed a novel luminescent nanochip technology for accurate detection of sweat glucose, with dual catalytic activity for sensitive detection and monitoring of glucose levels in different biological samples.
Accurate sweat glucose detection is a promising alternative to invasive finger-prick blood tests, allowing for self-monitoring of blood glucose with good patient compliance. In this study, we have developed a tandem catalytic system, termed as a luminescent nanochip (LAON), which was composed of gold nanoparticles (AuNPs) and N-(aminobutyl)-N-(ethylisoluminol) (ABEI)-engineered oxygen-doped carbon nitride (O-g-C3N4), for chemiluminescent detection of sweat glucose. The LAON exhibits dual catalytic activity of glucose oxidase and peroxidase and can not only oxidize glucose to generate H2O2 but catalyze H2O2-mediated luminol chemiluminescence, resulting in sensitive detection of glucose. We identify that the LAON can precisely detect glucose with a detection limit of 0.1 mu M, enabling us to measure glucose levels in different biological samples. Particularly, the LAON is capable of sensitively and accurately monitoring dynamic changes in sweat glucose during exercise. Therefore, the LAON provides an alternative approach to supersede invasive blood tests and may improve the management of diabetes mellitus.
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