4.5 Article

Application of the catalytic activity of gold nanoparticles for development of optical aptasensors

Journal

ANALYTICAL BIOCHEMISTRY
Volume 629, Issue -, Pages -

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2021.114307

Keywords

Gold nanoparticles; Aptasensor; Nanoparticles; Catalytic activity

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Biosensor technology is evolving with the development of aptasensors, which combine aptamer as a biological recognition element with gold nanoparticles (AuNPs) as probe to achieve high specificity, selectivity, and sensitivity. These sensors are cost-effective and capable of analyzing specific targets on-site using naked eye.
Biosensor technology is considered to be a great alternative in analytical techniques over the conventional methods. Among many recently developed techniques and devices, aptasensors are interesting because of their high specificity, selectivity and sensitivity. Combining aptamer as a biological recognition element with gold nanoparticles (AuNPs) as probe, are becoming more general owing to their beneficial properties, including low cost and ability to analyze specific targets on-site and using naked eye. Hydrogen bonds, nucleic acid hybridization, aptamer-target and antigen-antibody binding, Raman signature, enzyme inhibition, and enzymemimicking activity are main different sensing strategies exploited in AuNPs-based optical aptasensors. In this review article, we discussed the recent advances in optical aptasensors with a special emphasis on the catalytic activity property of AuNPs.

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