Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 21, Issue 11, Pages 3743-3749Publisher
WILEY
DOI: 10.1111/ajt.16765
Keywords
clinical decision-making; clinical research; practice; donors and donation; deceased; infection and infectious agents-viral; infectious disease; kidney transplantation; nephrology
Categories
Ask authors/readers for more resources
Although transplantation of solid organs from donors with active SARS-CoV-2 infection is not recommended, our study suggests that transplanting extrapulmonary organs, such as kidneys, from donors with detected SARS-CoV-2 RNA during evaluation is feasible and safe, with excellent outcomes for both patients and allografts during follow-up.
Transplantation of solid organs from donors with active SARS-CoV-2 infection has been advised against due to the possibility of disease transmission to the recipient. However, with the exception of lungs, conclusive data for productive infection of transplantable organs do not exist. While such data are awaited, the organ shortage continues to claim thousands of lives each year. In this setting, we put forth a strategy to transplant otherwise healthy extrapulmonary organs from SARS-CoV-2-infected donors. We transplanted 10 kidneys from five deceased donors with new detection of SARS-CoV-2 RNA during donor evaluation in early 2021. Kidney donor profile index ranged from 3% to 56%. All organs had been turned down by multiple other centers. Without clear signs or symptoms, the veracity of timing of SARS-CoV-2 infection could not be confirmed. With 8-16 weeks of follow-up, outcomes for all 10 patients and allografts have been excellent. All have been free of signs or symptoms of donor-derived SARS-CoV-2 infection. Our findings raise important questions about the nature of SARS-CoV-2 RNA detection in potential organ donors and suggest underutilization of exceptionally good extrapulmonary organs with low risk for disease transmission.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available