Single-stage long-segment tracheal transplantation

Tracheal transplantation has been envisioned as a viable option for reconstruction of long-segment tracheal defects. We report the first human single-stage long-segment tracheal transplantation. Narrow-band imaging and bronchoscopic biopsies demonstrate allograft vascularization and viable epithelial lining. The recipient was immunosuppressed with Tacrolimus, Mycophenolate mofetil, and corticosteroids. Six months after transplantation, the trachea is both functional and the patient is breathing without the need of a tracheostomy or stent.

Automated summary

Tracheal transplantation has been successfully performed in a human patient without the need for a tracheostomy or stent six months post-operation. The use of narrow-band imaging and bronchoscopic biopsies showed promising results in terms of allograft vascularization and viable epithelial lining. The recipient was immunosuppressed with a combination of Tacrolimus, Mycophenolate mofetil, and corticosteroids.