4.3 Article

Liver proteome response to torpor in a basoendothermic mammal, Tenrec ecaudatus, provides insights into the evolution of homeothermy

Publisher

AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpregu.00150.2021

Keywords

hibernation; liver; proteome; tenrec; torpor

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Funding

  1. College Research Fund grant (University of the Pacific)
  2. National Science Foundation [IOB 0448396, IOS 1655091]

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The study on tenrecs reveals that there is significant variability in liver protein abundance during torpor, indicating poor control of proteostasis. Compared to active warm animals, protein abundance in active cold and torpid tenrecs is more unstable.
Many mammals use adaptive heterothermy (e.g., torpor, hibernation) to reduce metabolic demands of maintaining high body temperature (Tb). Torpor is typically characterized by coordinated declines in Tb and metabolic rate (MR) followed by active rewarming. Most hibernators experience periods of euthermy between bouts of torpor during which homeostatic processes are restored. In contrast, the common tenrec, a basoendothermic Afrotherian mammal, hibernates without interbout arousals and displays extreme flexibility in Tb and MR. We investigated the molecular basis of this plasticity in tenrecs by profiling the liver proteome of animals that were active or torpid with high and more stable Tb (-32 degrees C) or lower Tb (-14 degrees C). We identified 768 tenrec liver proteins, of which 50.9% were differentially abundant between torpid and active animals. Protein abundance was significantly more variable in active cold and torpid compared with active warm animals, suggesting poor control of proteostasis. Our data suggest that torpor in tenrecs may lead to mismatches in protein pools due to poor coordination of anabolic and catabolic processes. We propose that the evolution of endothermy leading to a more realized homeothermy of boreoeutherians likely led to greater coordination of homeostatic processes and reduced mismatches in thermal sensitivities of metabolic pathways.

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