4.7 Article

CD47 and thrombospondin-1 regulation of mitochondria, metabolism, and diabetes

Related references

Note: Only part of the references are listed.
Article Medical Laboratory Technology

Human obese white adipose tissue sheds depot-specific extracellular vesicles and reveals candidate biomarkers for monitoring obesity and its comorbidities

Tamara Camino et al.

Summary: This study characterized the protein cargo of extracellular vesicles (EVs) released by adipose tissue (AT) in obese individuals using mass spectrometry analysis. The results revealed that EVs shed by visceral adipose tissue (VAT) in obese individuals contained more inflammation-related proteins compared to those shed by subcutaneous adipose tissue (SAT). Additionally, specific proteins identified in the EVs were associated with disease status and could serve as candidate biomarkers. These findings provide important insights into the mechanisms underlying obesity and related metabolic disorders.

TRANSLATIONAL RESEARCH (2022)

Article Pharmacology & Pharmacy

Activation of soluble guanylyl cyclase signalling with cinaciguat improves impaired kidney function in diabetic mice

Manuela Harloff et al.

Summary: The study demonstrated the beneficial effects of sGC activator cinaciguat in treating diabetic nephropathy in a mouse model. Activation of sGC may be a potential therapy option for patients with Type 1 diabetes.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Article Endocrinology & Metabolism

Obesity as a risk factor forCOVID-19 mortality in women and men in theUKbiobank: Comparisons with influenza/pneumonia and coronary heart disease

Sanne A. E. Peters et al.

Summary: This study using data from the UK Biobank found that obesity is associated with an increased risk of COVID-19, influenza/pneumonia, and coronary heart disease mortality, with a higher BMI showing stronger effects on COVID-19 mortality in women compared to men.

DIABETES OBESITY & METABOLISM (2021)

Article Endocrinology & Metabolism

Insulin-Stimulated Muscle Glucose Uptake and Insulin Signaling in Lean and Obese Humans

Paola A. Ramos et al.

Summary: The study found that there were no defects in insulin receptor signaling at the Akt/AS160 level in the muscles of obese individuals, indicating uncertainties in the mechanism of muscle insulin resistance in obesity.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Article Health Care Sciences & Services

Anti-Ageing Protein β-Klotho Rejuvenates Diabetic Stem Cells for Improved Gene-Activated Scaffold Based Wound Healing

Meenakshi Suku et al.

Summary: The study shows that pre-treatment with beta-klotho protein promotes inflammatory signal pruning, enhances the pro-angiogenic response of diabetic stem cells, and accelerates the cellular expression of matrix proteins, effectively speeding up the functional development of diabetic stem cells for wound healing applications.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Article Medicine, Research & Experimental

Mild hyperbaric oxygen exposure attenuates rarefaction of capillary vessels in streptozotocin-induced diabetic soleus muscle in rats

Masayuki Tanaka et al.

Summary: The study found that mild hyperbaric oxygen exposure helps alleviate capillary rarefaction in diabetic rats' skeletal muscles, partially restoring capillary diameter and volume, suppressing the expression of the anti-angiogenic protein TSP-1, and promoting the expression of the pro-angiogenic protein MDM-2.

BIOMEDICAL RESEARCH-TOKYO (2021)

Article Gastroenterology & Hepatology

Macrophage-derived thrombospondin 1 promotes obesity-associated non-alcoholic fatty liver disease

Taesik Gwag et al.

Summary: The study demonstrates that macrophage-derived TSP1 plays a significant role in the development and progression of obesity-associated NAFLD/NASH, suggesting it could serve as a therapeutic target for this disease.

JHEP REPORTS (2021)

Review Surgery

Gut Microbiota in Patients with Morbid Obesity Before and After Bariatric Surgery: a Ten-Year Review Study (2009-2019)

Spyridon G. Koulas et al.

Summary: Changes in gut microbiota composition and function impact the metabolic functions in obese patients, mainly caused by a Western-style diet; a deeper understanding of gut microbes is essential for the development of new therapeutic strategies.

OBESITY SURGERY (2021)

Article Cell Biology

Thrombospondin-1 in maladaptive aging responses: a concept whose time has come

Jeffrey S. Isenberg et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Suppression of Endothelial AGO1 Promotes Adipose Tissue Browning and Improves Metabolic Dysfunction

Xiaofang Tang et al.

CIRCULATION (2020)

Review Endocrinology & Metabolism

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Decio L. Eizirik et al.

NATURE REVIEWS ENDOCRINOLOGY (2020)

Review Endocrinology & Metabolism

Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications

Linhao Xu et al.

JOURNAL OF DIABETES RESEARCH (2020)

Article Endocrinology & Metabolism

CD47 decline in pancreatic islet cells promotes macrophage-mediated phagocytosis in type I diabetes

Jing Zhang et al.

WORLD JOURNAL OF DIABETES (2020)

Article Multidisciplinary Sciences

Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade

Ying Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biology

CD47 differentially regulates white and brown fat function

Heather Norman-Burgdolf et al.

BIOLOGY OPEN (2020)

Review Physiology

Role of Bile Acids in Bariatric Surgery

Wenting Wang et al.

FRONTIERS IN PHYSIOLOGY (2019)

Review Endocrinology & Metabolism

Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review

Jeroen M. K. de Filette et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2019)

Article Multidisciplinary Sciences

Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH)

Jessica Min-DeBartolo et al.

PLOS ONE (2019)

Article Physiology

Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice

Enrico M. Novelli et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2019)

Review Biochemistry & Molecular Biology

Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease

Joanne E. Murphy-Ullrich et al.

MATRIX BIOLOGY (2018)

Article Multidisciplinary Sciences

Replication confers β cell immaturity

Sapna Puri et al.

NATURE COMMUNICATIONS (2018)

Article Cell Biology

Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1

W. Christopher Risher et al.

JOURNAL OF CELL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Adipokines and Non-Alcoholic Fatty Liver Disease: Multiple Interactions

Timon E. Adolph et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

Thrombospondin-1, Free Radicals, and the Coronary Microcirculation: The Aging Conundrum

Amanda J. LeBlanc et al.

ANTIOXIDANTS & REDOX SIGNALING (2017)

Review Cardiac & Cardiovascular Systems

Matricellular protein thrombospondin-1 in pulmonary hypertension: multiple pathways to disease

Natasha M. Rogers et al.

CARDIOVASCULAR RESEARCH (2017)

Article Biochemistry & Molecular Biology

CD47 and Nox1 Mediate Dynamic Fluid-Phase Macropinocytosis of Native LDL

Gabor Csanyi et al.

ANTIOXIDANTS & REDOX SIGNALING (2017)

Article Endocrinology & Metabolism

Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis

Dan Zhu et al.

DIABETES (2017)

Review Biochemistry & Molecular Biology

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

Luong Dai Ly et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2017)

Article Cardiac & Cardiovascular Systems

HIF-2 alpha-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction

David Labrousse-Arias et al.

CARDIOVASCULAR RESEARCH (2016)

Article Biochemistry & Molecular Biology

Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway

Daniel A. Cunha et al.

CELL DEATH AND DIFFERENTIATION (2016)

Article Medical Laboratory Technology

High-glucose environment increased thrombospondin-1 expression in keratinocytes via DNA hypomethylation

Cheng-Che E. Lan et al.

TRANSLATIONAL RESEARCH (2016)

Article Immunology

Characterization of human organ donors testing positive for type 1 diabetes-associated autoantibodies

A. Wiberg et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2015)

Review Medicine, General & Internal

Nonalcoholic Fatty Liver Disease A Systematic Review

Mary E. Rinella

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

Article Biochemistry & Molecular Biology

Cleavage of Signal Regulatory Protein α (SIRPα) Enhances Inflammatory Signaling

James D. Londino et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

CD47 Receptor Globally Regulates Metabolic Pathways That Control Resistance to Ionizing Radiation

Thomas W. Miller et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Endocrinology & Metabolism

Thrombospondin 1 as a novel biological marker of obesity and metabolic syndrome

Yoshiyuki Matsuo et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2015)

Article Multidisciplinary Sciences

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

Huimin Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Tissue-based map of the human proteome

Mathias Uhlen et al.

SCIENCE (2015)

Article Biochemistry & Molecular Biology

Oxidized LDL-bound CD36 recruits an Na+/K+-ATPase-Lyn complex in macrophages that promotes atherosclerosis

Yiliang Chen et al.

SCIENCE SIGNALING (2015)

Article Biochemistry & Molecular Biology

Oxidized LDL-bound CD36 recruits an Na+/K+-ATPase-Lyn complex in macrophages that promotes atherosclerosis

Yiliang Chen et al.

SCIENCE SIGNALING (2015)

Article Endocrinology & Metabolism

Inhibition of NADPH oxidase-1 preserves beta cell function

Jessica R. Weaver et al.

DIABETOLOGIA (2015)

Review Biochemistry & Molecular Biology

CD47 signaling pathways controlling cellular differentiation and responses to stress

David R. Soto-Pantoja et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Current understanding of the thrombospondin-1 interactome

Andrea Resovi et al.

MATRIX BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Revisiting the matricellular concept

Joanne E. Murphy-Ullrich et al.

MATRIX BIOLOGY (2014)

Review Biochemistry & Molecular Biology

Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease

Natasha M. Rogers et al.

MATRIX BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Thrombospondin-1 and CD47 signaling regulate healing of thermal injury in mice

David R. Soto-Pantoja et al.

MATRIX BIOLOGY (2014)

Article Cardiac & Cardiovascular Systems

Cardiac CD47 Drives Left Ventricular Heart Failure Through Ca2+-CaMKII-Regulated Induction of HDAC3

Maryam Sharifi-Sanjani et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2014)

Article Endocrinology & Metabolism

Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation

Ping Kong et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)

Article Gastroenterology & Hepatology

Genome-wide transcriptome analysis identifies novel gene signatures implicated in human chronic liver disease

Rana V. Smalling et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Article Hematology

Thrombospondin-1 Regulates Blood Flow via CD47 Receptor Mediated Activation of NADPH Oxidase 1

Gabor Csanyi et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

Article Gastroenterology & Hepatology

Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease

Norberto C. Chavez-Tapia et al.

BMC GASTROENTEROLOGY (2012)

Article Cardiac & Cardiovascular Systems

Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1

Philip M. Bauer et al.

CARDIOVASCULAR RESEARCH (2012)

Article Urology & Nephrology

Activation of Parenchymal CD47 Promotes Renal Ischemia-Reperfusion Injury

Natasha M. Rogers et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)

Article Endocrinology & Metabolism

Role of Thrombospondin-2 in Murine Adipose Tissue Angiogenesis and Development

Matthias Van Hul et al.

OBESITY (2012)

Review Medicine, Research & Experimental

T-cell-mediated immunological barriers to xenotransplantation

Joseph Scalea et al.

XENOTRANSPLANTATION (2012)

Article Cardiac & Cardiovascular Systems

Higher Plasma Thrombospondin-1 Levels in Patients With Coronary Artery Disease and Diabetes Mellitus

Kyu-Young Choi et al.

KOREAN CIRCULATION JOURNAL (2012)

Article Endocrinology & Metabolism

Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for β-Cell Function

Johan Olerud et al.

DIABETES (2011)

Article Biochemistry & Molecular Biology

Glucose and insulin modify thrombospondin 1 expression and secretion in primary adipocytes from diet-induced obese rats

Diego F. Garcia-Diaz et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47

Elfaridah P. Frazier et al.

MATRIX BIOLOGY (2011)

Article Cardiac & Cardiovascular Systems

Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation

Eileen M. Bauer et al.

CARDIOVASCULAR RESEARCH (2010)

Article Biochemistry & Molecular Biology

Thrombospondin-1 Inhibits VEGF Receptor-2 Signaling by Disrupting Its Association with CD47

Sukhbir Kaur et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Endocrinology & Metabolism

Glucose inhibits angiogenesis of isolated human pancreatic islets

S. Dubois et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2010)

Article Multidisciplinary Sciences

Amyloid-β Inhibits No-cGMP Signaling in a CD36-and CD47-Dependent Manner

Thomas W. Miller et al.

PLOS ONE (2010)

Review Medicine, General & Internal

The Morbidity and Mortality Associated With Overweight and Obesity in Adulthood A Systematic Review

Matthias Lenz et al.

DEUTSCHES ARZTEBLATT INTERNATIONAL (2009)

Article Biochemistry & Molecular Biology

Differential Interactions of Thrombospondin-1,-2, and-4 with CD47 and Effects on cGMP Signaling and Ischemic Injury Responses

Jeff S. Isenberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress

Jeff S. Isenberg et al.

MATRIX BIOLOGY (2009)

Review Biochemistry & Molecular Biology

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

Roy L. Silverstein et al.

SCIENCE SIGNALING (2009)

Article Cell Biology

Radioprotection in Normal Tissue and Delayed Tumor Growth by Blockade of CD47 Signaling

Justin B. Maxhimer et al.

SCIENCE TRANSLATIONAL MEDICINE (2009)

Article Hematology

Blocking Thrombospondin-1/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia

Jeff S. Isenberg et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Drp1 mediates caspase-independent type III cell death in normal and leukemic cells

Marlene Bras et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake

Jeff S. Isenberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Endocrinology & Metabolism

Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes

Xianquan Li et al.

DIABETES (2006)

Article Multidisciplinary Sciences

Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells

Zhidan Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1

Jeff S. Isenberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Cell Biology

Nitric oxide and mitochondrial biogenesis

Enzo Nisoli et al.

JOURNAL OF CELL SCIENCE (2006)

Article Multidisciplinary Sciences

Modelling the onset of Type 1 diabetes:: can impaired macrophage phagocytosis make the difference between health and disease?

AFM Marée et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2006)

Article Endocrinology & Metabolism

Modulation of angiogenesis during adipose tissue development in murine models of obesity

G Voros et al.

ENDOCRINOLOGY (2005)

Article Multidisciplinary Sciences

Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1

LA Ridnour et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

CD47 augments Fas/CD95-mediated apoptosis

PP Manna et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Class B scavenger receptor-mediated intestinal absorption of dietary ß-carotene and cholesterol

A van Bennekum et al.

BIOCHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Neuronal roles of the integrin-associated protein (IAP/CD47) in developing cortical neurons

T Numakawa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Physiology

Brown adipose tissue: Function and physiological significance

B Cannon et al.

PHYSIOLOGICAL REVIEWS (2004)

Article Biochemistry & Molecular Biology

CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis

L Lamy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)