Is Lactoferrin Supplementation Beneficial for All Preterm Infants?

Objective Human milk (HM) has antibacterial properties due to the presence of immune-modulators, including lactoferrin (LF). This study will determine effect(s) of HM maturation, fortification, and storage conditions on LF levels and its antibacterial properties. Study Design HM samples ( n = 30) were obtained from preterm and term mothers. The LF levels were analyzed by ELISA, and the antibacterial activity was measured after inoculation with Escherichia coli . Results The highest level of LF in preterm HM was observed in the first week of lactation. However, storage of preterm HM at 4 degrees C decreased LF levels significantly. Both LF levels and antibacterial activity in preterm HM was lower compared with term HM, but significantly higher than donor HM even after HM-based fortification. LF supplementation of donor HM improved its antibacterial activity. Conclusion Preterm infants fed donor HM, formula, or stored HM at 4 degrees C may benefits from LF supplementation to improve HM antibacterial properties.

Automated summary

This study investigates the effects of HM maturation, fortification, and storage conditions on the levels of lactoferrin (LF) and its antibacterial properties. The results show that the highest LF levels are observed in preterm HM during the first week of lactation, but storage at 4 degrees C significantly decreases LF levels. LF levels and antibacterial activity in preterm HM are lower compared to term HM but higher than donor HM even after HM-based fortification.