A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease

Article Health Care Sciences & Services

Examining the Potential Impact of Race Multiplier Utilization in Estimated Glomerular Filtration Rate Calculation on African-American Care Outcomes

Salman Ahmed et al.

Summary: This study reveals a significant impact of race-adjusted eGFR on the care provided to the African-American CKD patient population.

JOURNAL OF GENERAL INTERNAL MEDICINE (2021)

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Article Urology & Nephrology

A New Panel-Estimated GFR, Including β2-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population

Lesley A. Inker et al.

Summary: The study suggests that GFR estimation using creatinine and cystatin C is more accurate but requires specification of race. Alternatively, using beta 2-microglobulin and beta-trace protein as filtration markers can reduce the influence of race and improve accuracy.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Editorial Material Urology & Nephrology

Race-Free Biomarkers to Quantify Kidney Function: Health Equity Lessons Learned From Population-Based Research

Nwamaka D. Eneanya et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Article Medicine, General & Internal

Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate A Cross-sectional Analysis of Pooled Data

Hans Pottel et al.

Summary: A new SCr-based equation, combining design features of the FAS and CKD-EPI equations, has been developed and validated to estimate glomerular filtration rate more accurately, especially during the transition from adolescence to adulthood. The equation shows low bias and fewer estimation errors across the full age spectrum.

ANNALS OF INTERNAL MEDICINE (2021)

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Article Urology & Nephrology

Reassessing the Inclusion of Race in Diagnosing Kidney Diseases: An Interim Report From the NKF-ASN Task Force

Cynthia Delgado et al.

Summary: The report discusses the controversy surrounding the inclusion of race in GFR estimation, as well as the evidence and values that inform these viewpoints. Several different approaches to estimate GFR have been proposed to address the issue, which will be evaluated and recommended in subsequent phases.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Letter Medicine, General & Internal

Removing Race From Kidney Function Estimates Reply

James A. Diao et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Letter Urology & Nephrology

Black Race Coefficient in GFR Estimation and Diabetes Medications in CKD: National Estimates

Carl P. Walther et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Urology & Nephrology

National Estimates of CKD Prevalence and Potential Impact of Estimating Glomerular Filtration Rate Without Race

Vishal Duggal et al.

Summary: Removing race adjustment from the CKD-EPI eGFR would double the estimated prevalence of CKD among Black adults in the United States, impacting a number of drug dosing decisions and potentially improving the accuracy of kidney failure risk prediction for higher-risk Black adults.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Medicine, General & Internal

Association of Race/Ethnicity, Gender, and Socioeconomic Status With Sodium-Glucose Cotransporter 2 Inhibitor Use Among Patients With Diabetes in the US

Lauren A. Eberly et al.

Summary: This study showed that Black and female patients as well as those with low socioeconomic status were less likely to receive SGLT2 inhibitor treatment among patients with type 2 diabetes in the US.

JAMA NETWORK OPEN (2021)

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Article Oncology

Effect of removing race from glomerular filtration rate-estimating equations on anticancer drug dosing and eligibility: a retrospective analysis of National Cancer Institute phase 1 clinical trial participants

Morgan A. Casal et al.

Summary: This study aimed to investigate the impact of removing race from the CKD-EPI equation on dosing and eligibility for anticancer drugs. The results showed that removing race led to a lower eGFR calculation for Black patients, resulting in more patients being excluded from receiving anticancer therapy, potentially leading to undertreatment of Black cancer patients.

LANCET ONCOLOGY (2021)

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Article Medicine, General & Internal

Trends in Diabetes Treatment and Control in US Adults, 1999-2018

Michael Fang et al.

Summary: The study found that after more than a decade of progress, glycemic and blood-pressure control declined in U.S. adults with diabetes, while lipid control plateaued.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Endocrinology & Metabolism