Journal
ALZHEIMERS & DEMENTIA
Volume 18, Issue 1, Pages 127-141Publisher
WILEY
DOI: 10.1002/alz.12378
Keywords
aging; Alzheimer' s disease; epidemiology; magnetic resonance imaging; periodontal diseases
Categories
Funding
- National Institutes of Health [U01AG024904, RF1AG059421]
- European Union Joint Programme-Neurodegenerative Disease Research [01ED1615]
- Department of Defense [W81XWH-12-2-0012]
- Federal Ministry of Education and Research [03IS2061A]
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Through a study of 177 periodontally treated patients and 409 untreated subjects, it was found that periodontal treatment has a positive effect on AD-related brain atrophy, while the effect on brain aging remains uncertain.
Introduction We investigated the relationship between periodontal treatment and pre-clinical Alzheimer's disease (AD). Methods In this quasi-experimental design, 177 periodontally treated patients from the Greifswald Approach to Individualized Medicine cohort, which used the same protocols as the population-based Study of Health in Pomerania TREND (SHIP-TREND), and 409 untreated subjects from SHIP-TREND were analyzed. Subjects were younger than 60 years at the magnetic resonance imaging examination, with a median observation period of 7.3 years. Imaging markers for brain atrophy in late-onset AD and brain aging were used as the outcomes. Results Robust to sensitivity analyses, periodontal treatment had a favorable effect on AD-related brain atrophy (-0.41; 95% confidence interval: -0.70 to -0.12; P = .0051), which corresponds to a shift from the 50th to the 37th percentile of the outcome distribution. For brain aging, the treatment effect was uncertain. Conclusion Periodontitis is related to pre-clinical AD in our population.
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