Journal
ALZHEIMERS & DEMENTIA
Volume 18, Issue 3, Pages 422-433Publisher
WILEY
DOI: 10.1002/alz.12410
Keywords
Alzheimer's disease; amyloid positron emission tomography; cognition; corpus callosum; executive functions; fluid-attenuated inversion recovery; memory; magnetic resonance imaging; splenium; white matter hyperintensities
Categories
Funding
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Programme Hospitalier de Recherche Clinique [PHRCN2011-A01493-38, PHRCN2012 12006-0347]
- Agence Nationale de la Recherche [ANRLONGVIE 2007]
- Fondation Plan Alzheimer [2008-2012]
- Fondation LECMA-Vaincre Alzheimer [13732]
- Fondation Alzheimer
- Fondation d'entreprise MMAdes Entrepreneurs du Futur
- Association France Alzheimer etmaladies apparentees
- Region Basse-Normandie
- Agence regionale de sante Auvergne-Rhone-Alpes
- European Union's Horizon 2020 Research and Innovation Program [667696]
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White matter hyperintensities (WMH) in Alzheimer's disease (AD), especially in the splenium of the corpus callosum (S-CC), are associated with decreased cognition independently from amyloid deposition and atrophy. This study highlights the clinical relevance of posterior WMH, particularly S-CC WMH, in AD.
Introduction White matter hyperintensities (WMH) are often described in Alzheimer's disease (AD), but their topography and specific relationships with cognition remain unclear. Methods Regional WMH were estimated in 54 cognitively impaired amyloid beta-positive AD (A beta pos-AD), compared to 40 cognitively unimpaired amyloid beta-negative older controls (A beta neg-controls) matched for vascular risk factors. The cross-sectional association between regional WMH volume and cognition was assessed within each group, controlling for cerebral amyloid burden, global cortical atrophy, and hippocampal atrophy. Results WMH volume was larger in A beta pos-AD compared to A beta neg-controls in all regions, with the greatest changes in the splenium of the corpus callosum (S-CC). In A beta pos-AD patients, larger total and regional WMH volume, especially in the S-CC, was strongly associated with decreased cognition. Discussion WMH specifically contribute to lower cognition in AD, independently from amyloid deposition and atrophy. This study emphasizes the clinical relevance of WMH in AD, especially posterior WMH, and most notably S-CC WMH.
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