Journal
ALZHEIMERS & DEMENTIA
Volume 17, Issue 12, Pages 2043-2055Publisher
WILEY
DOI: 10.1002/alz.12350
Keywords
Alzheimer' s disease; early‐ onset; EOAD; LEADS; YOAD; young onset
Categories
Funding
- Alzheimer's Association [LEADS GENETICS-19-639372, U01 AG016976, P30 AG010133, P50 AG008702, P50 AG025688, P50 AG005146, P30 AG062421, P30 AG062422, P50 AG023501, P30 AG010124, P30 AG013854, P50 AG005681]
- [R56 AG057195]
- [U01AG6057195]
- [U24AG021886]
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The Longitudinal EOAD Study (LEADS) aims to track EOAD patients, define their clinical, imaging, and fluid biomarker characteristics, develop sensitive cognitive and biomarker measures for future use, and establish a trial-ready network to advance Alzheimer's disease research.
Patients with early-onset Alzheimer's disease (EOAD) are commonly excluded from large-scale observational and therapeutic studies due to their young age, atypical presentation, or absence of pathogenic mutations. The goals of the Longitudinal EOAD Study (LEADS) are to (1) define the clinical, imaging, and fluid biomarker characteristics of EOAD; (2) develop sensitive cognitive and biomarker measures for future clinical and research use; and (3) establish a trial-ready network. LEADS will follow 400 amyloid beta (A beta)-positive EOAD, 200 A beta-negative EOnonAD that meet National Institute on Aging-Alzheimer's Association (NIA-AA) criteria for mild cognitive impairment (MCI) or AD dementia, and 100 age-matched controls. Participants will undergo clinical and cognitive assessments, magnetic resonance imaging (MRI), [F-18]Florbetaben and [F-18]Flortaucipir positron emission tomography (PET), lumbar puncture, and blood draw for DNA, RNA, plasma, serum and peripheral blood mononuclear cells, and post-mortem assessment. To develop more effective AD treatments, scientists need to understand the genetic, biological, and clinical processes involved in EOAD. LEADS will develop a public resource that will enable future planning and implementation of EOAD clinical trials.
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