Journal
AIDS RESEARCH AND HUMAN RETROVIRUSES
Volume 37, Issue 12, Pages 978-984Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2021.0100
Keywords
HIV; URF; recombination; NFLG
Categories
Funding
- NSFC [31900157]
- state key laboratory of Pathogen and Biosecurity (AMMS)
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Two novel URFs, consisting of CRF01_AE and CRF07_BC, were identified in Shijiazhuang, China. The CRF01_AE segments traced back to cluster 4 of CRF01_AE strains, which are prevalent among HIV-1 infections through MSM in China. This study suggests that new URFs are gradually developing and spreading, indicating the need for adjustments to past prevention strategies.
Unique recombinant forms (URFs) are more likely developed among HIV-1 infections through men who have sex with men (MSM) because of cocirculation of multiple subtypes. In this study, two novel URFs deriving from two HIV-positive subjects (HB010014, HB010063) were identified in Shijiazhuang, Hebei province, China, and two sequences formed a distinct monophyletic cluster. Further recombination analysis showed that of two new URFs were consisted of circulating recombinant form (CRF)01_AE and CRF07_BC. The subregion phylogenetic analysis indicated that CRF01_AE segments were traced back to cluster 4 of CRF01_AE strains, which were prevalent among HIV-1 infections through MSM in China. New URFs being developing gradually and spreading released that more and more novel recombinant strains of HIV-1 could be developed, which means that the past prevention strategies need to be adjusted.
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