Journal
AGING-US
Volume 13, Issue 11, Pages 14968-14988Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.203049
Keywords
colorectal cancer liver metastases; prognosis; bioinformatics analysis; competing endogenous RNA (ceRNA)
Categories
Funding
- National Key Research and Development Program of China [2018YFE0127300]
- Primary Research and Development Plan of Jiangsu Province [BE2019759]
Ask authors/readers for more resources
The study identified a ceRNA regulatory network involving ZEB1-AS1, miR-335-5p, and APOC1, which plays a significant role in colorectal cancer (CRC) and colorectal liver metastases (CRLM). This network provides valuable predictors for prognosis and potential therapeutic targets for CRC patients.
Liver metastasis is a leading cause of death in patients with colorectal cancer (CRC). Increasing evidence demonstrates that competing endogenous RNA (ceRNA) networks play important roles in malignant cancers. The purpose of this study was to identify molecular markers and build a ceRNA network as a significant predictor of colorectal liver metastases (CRLM). By integrated bioinformatics analysis, we found that apolipoprotein C1 (APOC1) was upregulated in CRLM and associated with prognosis in patients with CRC and thereby established an APOC1-dependent ceRNA network. By survival analysis, expression analysis, and correlation analysis of each element in the ceRNA network, we identified that ZEB1-AS1, miR-335-5p and APOC1 regulated each other. We further experimentally confirmed that ZEB1-AS1 promoted a CRC progression via regulating the expression of miR-335-5p that controlled the expression of APOC1. Our findings indicate that the ZEB1-AS1-miR-335-5p-APOC1 ceRNA regulatory network is significantly valuable for better prognosis of patients with CRC and as a new therapeutic target for the treatment of CRLM.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available