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The pathological process underlying Alzheimer's disease in individuals under thirty
Heiko Braak et al.
ACTA NEUROPATHOLOGICA (2011)
Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States
Walter A. Rocca et al.
ALZHEIMERS & DEMENTIA (2011)
Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments
Vivek Swarup et al.
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Morphological changes in nerve cells during normal aging
Ennio Pannese
BRAIN STRUCTURE & FUNCTION (2011)
Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus
Juan M. Encinas et al.
CELL STEM CELL (2011)
Technical approaches for mouse models of human disease
Monica J. Justice et al.
DISEASE MODELS & MECHANISMS (2011)
Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb
Tomoko Kuwabara et al.
EMBO MOLECULAR MEDICINE (2011)
Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegeneration
Yuen-Sum Lau et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2011)
Lipofuscin inhibits the proteasome by binding to surface motifs
Annika Hoehn et al.
FREE RADICAL BIOLOGY AND MEDICINE (2011)
Distinct DNA methylation changes highly correlated with chronological age in the human brain
Dena G. Hernandez et al.
HUMAN MOLECULAR GENETICS (2011)
Exercise training increases mitochondrial biogenesis in the brain
Jennifer L. Steiner et al.
JOURNAL OF APPLIED PHYSIOLOGY (2011)
Dietary restriction of mice on a high-fat diet induces substrate efficiency and improves metabolic health
Loes P. M. Duivenvoorde et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2011)
Accurate Quantification of More Than 4000 Mouse Tissue Proteins Reveals Minimal Proteome Changes During Aging
Dirk M. Walther et al.
MOLECULAR & CELLULAR PROTEOMICS (2011)
Caloric restriction
John R. Speakman et al.
MOLECULAR ASPECTS OF MEDICINE (2011)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Darren J. Baker et al.
NATURE (2011)
Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain
Na Li et al.
NEUROBIOLOGY OF AGING (2011)
Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2
David Ramonet et al.
PLOS ONE (2011)
Molecular Insights into the Pathogenesis of Alzheimer's Disease and Its Relationship to Normal Aging
Alexei A. Podtelezhnikov et al.
PLOS ONE (2011)
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Daniel F. Egan et al.
SCIENCE (2011)
Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging
Douglas R. Green et al.
SCIENCE (2011)
Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging
Fernando G. Osorio et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Prostaglandin D2 and sleep/wake regulation
Yoshihiro Urade et al.
SLEEP MEDICINE REVIEWS (2011)
The metabolic footprint of aging in mice
Riekelt H. Houtkooper et al.
SCIENTIFIC REPORTS (2011)
Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice
Monique C. de Waard et al.
ACTA NEUROPATHOLOGICA (2010)
Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening
Chen-Yu Liao et al.
AGING CELL (2010)
Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates
Matthew D. Bruss et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
Jean -Philippe Coppe et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
Transgenic models for cytokine-induced neurological disease
Iain L. Campbell et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)
A Calorie-Restricted Diet Decreases Brain Iron Accumulation and Preserves Motor Performance in Old Rhesus Monkeys
Erik K. Kastman et al.
JOURNAL OF NEUROSCIENCE (2010)
Aging in Mouse Brain Is a Cell/Tissue-Level Phenomenon Exacerbated by Proteasome Loss
Lei Mao et al.
JOURNAL OF PROTEOME RESEARCH (2010)
Selective review of cognitive aging
Timothy A. Salthouse
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY (2010)
Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice
Alexis M. Stranahan et al.
NEUROBIOLOGY OF AGING (2010)
EFFECTS OF AEROBIC EXERCISE TRAINING ON COGNITIVE FUNCTION AND CORTICAL VASCULARITY IN MONKEYS
I. J. Rhyu et al.
NEUROSCIENCE (2010)
EXERCISE AND TIME-DEPENDENT BENEFITS TO LEARNING AND MEMORY
N. C. Berchtold et al.
NEUROSCIENCE (2010)
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
Marta M. Lipinski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Differential effects and rates of normal aging in cerebellum and hippocampus
Diana S. Woodruff-Pak et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Protein abundances are more conserved than mRNA abundances across diverse taxa
Jon M. Laurent et al.
PROTEOMICS (2010)
Extending Healthy Life Span-From Yeast to Humans
Luigi Fontana et al.
SCIENCE (2010)
ER and aging-Protein folding and the ER stress response
Nirinjini Naidoo
AGEING RESEARCH REVIEWS (2009)
The overexpression of major antioxidant enzymes does not extend the lifespan of mice
Viviana I. Perez et al.
AGING CELL (2009)
Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C-elegans
Eric L. Greer et al.
AGING CELL (2009)
The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging
Daniel Edgar et al.
AGING-US (2009)
Uncoupling protein-2 regulates lifespan in mice
Zane B. Andrews et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)
Protein aggregation as a paradigm of aging
Ariel B. Lindner et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)
Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells
Maximiliano A. D'Angelo et al.
CELL (2009)
The human brain in numbers: a linearly scaled-up primate brain
Suzana Herculano-Houzel
FRONTIERS IN HUMAN NEUROSCIENCE (2009)
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
Claudio Hetz et al.
GENES & DEVELOPMENT (2009)
Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant α-Synuclein
Xiao-Hong Lu et al.
JOURNAL OF NEUROSCIENCE (2009)
HDAC2 negatively regulates memory formation and synaptic plasticity
Ji-Song Guan et al.
NATURE (2009)
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
David E. Harrison et al.
NATURE (2009)
Senescence-Accelerated Mouse (SAM) with Special References to Neurodegeneration Models, SAMP8 and SAMP10 Mice
Toshio Takeda
NEUROCHEMICAL RESEARCH (2009)
MOLECULAR ORIGINS OF CANCER DNA Damage, Aging, and Cancer
Jan H. J. Hoeijmakers
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat
Viviana I. Perez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman et al.
SCIENCE (2009)
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Colin Selman et al.
SCIENCE (2009)
Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass-spectrometry based strategy
Graham M. West et al.
ANALYTICAL CHEMISTRY (2008)
The aging brain
Bruce A. Yankner et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2008)
Decreased enzyme activities of chaperones PD1 and BiP in aged mouse livers
Jonathan E. Nuss et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Mitochondria - A nexus for aging, calorie restriction, and sirtuins?
Leonard Guarente
CELL (2008)
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin
Thomas Dechat et al.
GENES & DEVELOPMENT (2008)
Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease
David Sulzer et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling
Nirinjini Naidoo et al.
JOURNAL OF NEUROSCIENCE (2008)
CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control
Jin-Na Min et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity
Marcia D. Antion et al.
LEARNING & MEMORY (2008)
The length of hippocampal cholinergic fibers is reduced in the aging brain
Athena Rebecca Ypsilanti et al.
NEUROBIOLOGY OF AGING (2008)
Evolution of the Aging Brain Transcriptome and Synaptic Regulation
Patrick M. Loerch et al.
PLOS ONE (2008)
Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism
Laurent Kappeler et al.
PLOS BIOLOGY (2008)
AGEMAP: A gene expression database for aging in mice
Jacob M. Zahn et al.
PLOS GENETICS (2007)
Inflammatory processes in the aging mouse brain: Participation of dendritic cells and T-cells
C. C. Stichel et al.
NEUROBIOLOGY OF AGING (2007)
Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease
Mary Y. Heng et al.
JOURNAL OF NEUROSCIENCE (2007)
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
Tohru Kitada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Mutant mice with small amounts of BubR1 display accelerated age-related gliosis
Tyler K. Hartman et al.
NEUROBIOLOGY OF AGING (2007)
Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease
Veerendra Kumar Madald Halagappa et al.
NEUROBIOLOGY OF DISEASE (2007)
Aging-associated vascular phenotype in mutant mice with low levels of BubR1
Takuya Matsumoto et al.
STROKE (2007)
Microglia derived from aging mice exhibit an altered inflammatory profile
Amanda Sierra et al.
GLIA (2007)
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
Yasumasa Yoshiyama et al.
NEURON (2007)
The role of mitochondrial DNA mutations in mammalian aging
Gregory C. Kujoth et al.
PLOS GENETICS (2007)
Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide
Christian Haass et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Gene Aging Nexus: a web database and data mining platform for microarray data on aging
Fei Pan et al.
NUCLEIC ACIDS RESEARCH (2007)
Hutchinson-Gifford Progeria syndrome: Review of the phenotype
Raoul C. M. Hennekam
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2006)
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Anna V. Molofsky et al.
NATURE (2006)
Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
Rebecca Radde et al.
EMBO REPORTS (2006)
Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet
Kristopher J. Bough et al.
ANNALS OF NEUROLOGY (2006)
Cellular environment facilitates protein accumulation in aged rat hippocampus
M. Paz Gavilan et al.
NEUROBIOLOGY OF AGING (2006)
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu et al.
NATURE (2006)
Stereological estimation of Purkinje neuron number in C57BL/6 mice and its relation to associative learning
D. S. Woodruff-Pak
NEUROSCIENCE (2006)
A hitchhiker's guide to behavioral analysis in laboratory rodents
N Sousa et al.
GENES BRAIN AND BEHAVIOR (2006)
Neural plasticity in the ageing brain
SN Burke et al.
NATURE REVIEWS NEUROSCIENCE (2006)
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
Piera Pasinelli et al.
NATURE REVIEWS NEUROSCIENCE (2006)
Lateralization of the vertebrate brain:: Taking the side of model systems
ME Halpern et al.
JOURNAL OF NEUROSCIENCE (2005)
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
I Varela et al.
NATURE (2005)
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
GC Kujoth et al.
SCIENCE (2005)
Extension of murine life span by overexpression of catalase targeted to mitochondria
SE Schriner et al.
SCIENCE (2005)
Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density
BD Eadie et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2005)
Overview of caloric restriction and ageing
EJ Masoro
MECHANISMS OF AGEING AND DEVELOPMENT (2005)
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
L Fontana et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Insulin and the insulin receptor in experimental models of learning and memory
WQ Zhao et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Insights into the ageing mind: A view from cognitive neuroscience
T Hedden et al.
NATURE REVIEWS NEUROSCIENCE (2004)
Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue
JS Henkel et al.
ANNALS OF NEUROLOGY (2004)
The aging brain: morphomolecular senescence of cortical circuits
PR Hof et al.
TRENDS IN NEUROSCIENCES (2004)
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
DJ Baker et al.
NATURE GENETICS (2004)
The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise
PA Adlard et al.
NEUROSCIENCE LETTERS (2004)
Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: Developing normative sleep values across the human lifespan
MM Ohayon et al.
SLEEP (2004)
The Collaborative Cross, a community resource for the genetic analysis of complex traits
G Churchill et al.
NATURE GENETICS (2004)
Premature ageing in mice expressing defective mitochondrial DNA polymerase
A Trifunovic et al.
NATURE (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
Aging of the human cerebellum: A stereological study
BB Andersen et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2003)
Inflammation is detrimental for neurogenesis in adult brain
CT Ekdahl et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Triple-transgenic model of Alzheimer's disease with plaques and tangles:: Intracellular Aβ and synaptic dysfunction
S Oddo et al.
NEURON (2003)
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
EJ Slow et al.
HUMAN MOLECULAR GENETICS (2003)
Effect of interpretive bias on research evidence
TJ Kaptchuk
BRITISH MEDICAL JOURNAL (2003)
Age-related loss of synapses in the frontal cortex of SAMP10 mouse: A model of cerebral degeneration
AS Shimada et al.
SYNAPSE (2003)
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
M Eriksson et al.
NATURE (2003)
Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice
SM Cerritelli et al.
MOLECULAR CELL (2003)
Ketogenic diet increases glutathione peroxidase activity in rat hippocampus
DR Ziegler et al.
NEUROCHEMICAL RESEARCH (2003)
Complex I-mediated reactive oxygen species generation:: modulation by cytochrome c and NAD(P)+ oxidation-reduction state
Y Kushnareva et al.
BIOCHEMICAL JOURNAL (2002)
The effects of normal aging on myelin and nerve fibers: A review
A Peters
JOURNAL OF NEUROCYTOLOGY (2002)
Lipofuscin: Mechanisms of age-related accumulation and influence on cell function
UT Brunk et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
Neuronal changes in normal human aging and Alzheimer's disease
HBM Uylings et al.
BRAIN AND COGNITION (2002)
Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53→Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice
MK Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Behavioral and neurochemical effects of wild-type and mutated human α-synuclein in transgenic mice
EK Richfield et al.
EXPERIMENTAL NEUROLOGY (2002)
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice
AM Pendás et al.
NATURE GENETICS (2002)
The mitochondrial-lysosomal axis theory of aging - Accumulation of damaged mitochondria as a result of imperfect autophagocytosis
UT Brunk et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)
The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation
FJ Sim et al.
JOURNAL OF NEUROSCIENCE (2002)
Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice
J Lee et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice
L Sörensen et al.
JOURNAL OF NEUROSCIENCE (2001)
Standardizing tests of mouse behavior: Reasons, recommendations, and reality
D Wahlsten
PHYSIOLOGY & BEHAVIOR (2001)
Ubiquitination of a new form of α-synuclein by parkin from human brain:: Implications for Parkinson's disease
H Shimura et al.
SCIENCE (2001)
BACE1 is the major β-secretase for generation of Aβ peptides by neurons
HB Cai et al.
NATURE NEUROSCIENCE (2001)
The effects of aging on gene expression in the hypothalamus and cortex of mice
CH Jiang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Neurological abnormalities in a knock-in mouse model of Huntington's disease
CH Lin et al.
HUMAN MOLECULAR GENETICS (2001)
Uncoupling protein 2 in the brain: distribution and function
D Richard et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2001)
Brain-derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice
WZ Duan et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
D Arsenijevic et al.
NATURE GENETICS (2000)
Wild-derived inbred mouse strains have short telomeres
MT Hemann et al.
NUCLEIC ACIDS RESEARCH (2000)
Age-related decline in chaperone-mediated autophagy
AM Cuervo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
J Lewis et al.
NATURE GENETICS (2000)
Gene-expression profile of the ageing brain in mice
CK Lee et al.
NATURE GENETICS (2000)
High-level neuronal expression of Aβ1-42 in wild-type human amyloid protein precursor transgenic mice:: Synaptotoxicity without plaque formation
L Mucke et al.
JOURNAL OF NEUROSCIENCE (2000)
Association between early-onset Parkinson's disease and mutations in the parkin gene
CB Lücking et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
Insulin receptors in the brain cortex of aging mice
A Zaia et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2000)
Possible involvement of proteasome inhibition in aging: implications for oxidative stress
JN Keller et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2000)