Journal
ADVANCES IN ANATOMIC PATHOLOGY
Volume 28, Issue 4, Pages 196-208Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PAP.0000000000000309
Keywords
bladder cancer; WHO classification; pathology; urothelial carcinoma; variant histology; subtypes; stage; pTNM; molecular classification of bladder cancer; immunotherapy
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The review focuses on effective reporting of bladder cancer, emphasizing new data and important concepts, particularly the significance of reporting bladder cancer with divergent differentiation and variant histologies.
The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder cancer focusing on important topics of high interest for the practicing surgical pathologist and urologist. This review represents the second of 2 manuscripts ensuing from this effort. Herein, we address the effective reporting of bladder cancer, focusing particularly on newly published data since the last 2016 World Health Organization (WHO) classification. In addition, this review focuses on the importance of reporting bladder cancer with divergent differentiation and variant (subtypes of urothelial carcinoma) histologies and the potential impact on patient care. We provide new recommendations for reporting pT1 staging in diagnostic pathology. Furthermore, we explore molecular evolution and classification, emphasizing aspects that impact the understanding of important concepts relevant to reporting and management of patients.
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