Nickel-Catalyzed Amination of Aryl Nitriles for Accessing Diarylamines through C-CN Bond Activation

A nickel-catalyzed amination to access diarylamines has been developed through C-CN bond activation of aryl nitriles with anilines. In this developed catalytic protocol, various aromatic and heteroaromatic nitriles could be utilized as the electrophiles to couple with substituted anilines. A diversity of diarylamines were obtained in 15-95% yields.

Automated summary

A new nickel-catalyzed amination method has been developed for the synthesis of diarylamines through C-CN bond activation of aryl nitriles with anilines. Various aromatic and heteroaromatic nitriles were used as electrophiles to couple with substituted anilines, resulting in a diverse range of diarylamines with yields ranging from 15% to 95%.