Visible-Light-Mediated Aerobic Oxidative C(sp3)-C(sp3) Bond Cleavage of Morpholine Derivatives Using 4CzIPN as a Photocatalyst

Herein, a metal-free strategy for the aerobic oxidative cleavage of the inert C(sp(3))-C(sp(3)) bond was developed. Deconstruction of morpholine derivatives was conducted using visible light as an energy source and O-2 as an oxidant under mild conditions. This procedure demonstrated suitable selectivity and functional group tolerance. Moreover, a possible mechanism involving a radical process was proposed based on a series of mechanism exploration and control experiments.

Automated summary

In this study, a metal-free strategy was developed for the aerobic oxidative cleavage of the inert C(sp(3))-C(sp(3)) bond using visible light as an energy source and O-2 as an oxidant under mild conditions. The procedure showed suitable selectivity and functional group tolerance, and a possible mechanism involving a radical process was proposed based on mechanism exploration and control experiments.