Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 31, Issue 30, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202100924
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Funding
- National Natural Science Foundation of China [51802227, 51872224]
- Zhejiang Provincial Basic Public Welfare Research program [LGF18H150008]
- Medical Health Science and Technology Project of Zhejiang Province [2019KY464]
- Wenzhou Science and Technology Bureau Project [ZY2019003, Y20190123, Y2020236]
- Special Support Program for High Level Talents of Shaanxi Province [7122200063]
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A conductive hydrogel scaffold with M2 phenotype-enabled properties has been developed to enhance diabetic wound repair by promoting anti-inflammation and antioxidant activities.
Diabetic wound healing still faces great challenges due to the excessive inflammation, easy infection, and impaired angiogenesis in wound beds. The immunoregulation of macrophages polarization toward M2 phenotype that facilitates the transition from inflammation to proliferation phase has been proved to be an effective way to improve diabetic wound healing. Herein, an M2 phenotype-enabled anti-inflammatory, antioxidant, and antibacterial conductive hydrogel scaffolds (GDFE) for producing rapid angiogenesis and diabetic wound repair are reported. The GDFE scaffolds are fabricated facilely through the dynamic crosslinking between polypeptide and polydopamine and graphene oxide. The GDFE scaffolds possess thermosensitivity, self-healing behavior, injectability, broad-spectrum antibacterial activity, antioxidant and anti-inflammatory ability, and electronic conductivity. GDFE effectively activates the polarization of macrophages toward M2 phenotype and significantly promotes the proliferation of dermal fibroblasts, the migration, and in vitro angiogenesis of endothelial cells through paracrine mechanisms. The in vivo results from a full-thickness diabetic wound model demonstrate that GDFE can rapidly promote the diabetic wound repair and skin regeneration, through fast anti-inflammation and angiogenesis and M2 macrophage polarization. This study provides highly efficient strategy for treating diabetic wound repair through designing the M2 polarization-enabled anti-inflammatory, antioxidant, and antibacterial bioactive materials.
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