Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 31, Issue 41, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202105265
Keywords
femtosecond laser microfabrication; Janus membranes; unidirectional liquid transport; wettability; wound dressing
Categories
Funding
- Fundamental Research Funds for the Central Universities [WK2090000016, WK5290000001, WK911000057]
- China Postdoctoral Science Foundation [2019M662190]
- Project of the Science and Technology Innovation of Anhui province [2017070802D146, 2018080402A009]
- Key Programs for Research and Development of Anhui Province [1704a0802153]
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The traditional dressings' hydrophilicity cannot effectively manage excessive biofluid, hindering wound healing, and current dressings also have problems with limited stretching capability. This study presents a Janus wound dressing with the function of unidirectional biofluid draining, accelerating wound healing. Additionally, amoxicillin powder is encapsulated on the surface of the dressing to prevent bacterial infection.
The intrinsic hydrophilicity of conventional dressings cannot achieve effective management of excessive biofluid around the wound bed, which inevitably causes infection and hinders wound healing. In addition, present dressings such as medical gauze or band aids have a limited stretching capability, which does not comply well with the skin deformation during muscle movement, thus impacting patient comfort. Herein, a Janus wound dressing is reported by assembling an external hydrophobic (HP) adhesive tape, a filter paper, and a polydimethylsiloxane (PDMS) Janus film. The PDMS Janus film as the primary dressing can unidirectionally remove biofluid away from the wound bed. The mechanism of the unidirectional biofluid transport is investigated, demonstrating that the stretching or bending of the Janus dressing is beneficial for unidirectional biofluid draining. It indicates that the Janus PDMS film has potential for practical applications on stretched or bended skin surface. In addition, in order to prevent bacterial infection, amoxicillin powder is uniformly encapsulated on the HP layer of Janus film, resulting in faster wound healing. This study is valuable for designing and fabricating next-generation dressings with high performance for clinical applications.
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