Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 173, Issue -, Pages 164-180Publisher
ELSEVIER
DOI: 10.1016/j.addr.2021.03.016
Keywords
Vaccine; Antigen; Extracellular vesicles; Outer membrane vesicles; Immunotherapy; Infection; Cancer
Categories
Funding
- German Academic Exchange Service (DAAD) [GERLS 91664644]
- Egyptian Ministry of Higher Education
- Federal Ministry of Education and Research, Germany [13XP5029A]
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EVs and MVs provide innovative avenues for safe and effective antigen delivery, with potential applications in anti-cancer vaccination immunotherapy and prophylactic vaccination against infectious diseases.
Antigen delivery has always been a challenge in scientific practice of vaccine formulation. Yet, mammalian extracellular vesicles (EVs) or bacterial membrane vesicles (MVs) provide an innovative avenue for safe and effective delivery of antigenic material. They include intrinsically loaded antigens from EV-secreting cells or extrinsically loaded antigens onto pre-formed vesicles. Interestingly, many studies shed light on potential novel anti-cancer vaccination immunotherapy for therapeutic applications from mammalian cell host-derived EVs, as well as conventional vaccination for prophylactic applications using bacterial cell-derived MVs against infectious diseases. Here, we discuss the rationale, status quo and potential for both vaccine applications using EVs. (c) 2021 Elsevier B.V. All rights reserved.
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