Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 176, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.addr.2021.113837
Keywords
Exosomes; Microvesicles; Therapeutic proteins; Cytoplasmic delivery; Liposomes; Macromolecules delivery; Vectorisation
Categories
Funding
- French National Research Agency (ANR) [ANR-20-CE09-0011-01]
- INCa-Canceropole GSO [2018-E14]
- Agence Nationale de la Recherche (ANR) [ANR-20-CE09-0011] Funding Source: Agence Nationale de la Recherche (ANR)
Ask authors/readers for more resources
Protein therapeutics offer higher specificity and lower toxicity compared to chemicals, with potential for broad application. Delivery systems are necessary for maximizing their biological potential, and extracellular vesicles (EVs) as natural protein nanocarriers show great promise.
Compared to chemicals that continue to dominate the overall pharmaceutical market, protein therapeutics offer the advantages of higher specificity, greater activity, and reduced toxicity. While nearly all existing therapeutic proteins were developed against soluble or extracellular targets, the ability for proteins to enter cells and target intracellular compartments can significantly broaden their utility for a myriad of exiting targets. Given their physical, chemical, biological instability that could induce adverse effects, and their limited ability to cross cell membranes, delivery systems are required to fully reveal their biological potential. In this context, as natural protein nanocarriers, extracellular vesicles (EVs) hold great promise. Nevertheless, if not present naturally, bringing an interest protein into EV is not an easy task. In this review, we will explore methods used to load extrinsic protein into EVs and compare these natural vectors to their close synthetic counterparts, liposomes/lipid nanoparticles, to induce intracellular protein delivery. (c) 2021 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available