Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 176, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.addr.2021.113885
Keywords
Biomaterial; Nucleic acid; Drug delivery; Tissue regeneration
Categories
Funding
- National Key Research and Development Program of China [2020YFA0908200]
- Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support [20171906]
- Shanghai talent development fund [2018099]
- China Postdoctoral Science Foundation [2021M692105]
- Youth development fund [KY2021602]
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Gene therapy for tissue regeneration is promising but faces limitations in vivo due to physiological obstacles. Biomaterial-based gene delivery systems can overcome stability issues and control overexpression of therapeutic genes, contributing to local production of regulatory factors.
Gene therapy is a promising novel method of tissue regeneration by stimulating or inhibiting key signaling pathways. However, their therapeutic applications in vivo are largely limited by several physiological obstacles, such as degradation of nucleases, impermeability of cell membranes, and transport to the desired intracellular compartments. Biomaterial-based gene delivery systems can overcome the problems of stability and local drug delivery, and can temporarily control the overexpression of therapeutic genes, leading to the local production of physiologically relevant levels of regulatory factors. But the gene delivery of biomaterials for tissue regeneration relies on multi-factor design. This review aims to outline the impact of gene delivery methods, therapeutic genes and biomaterials selection on this strategy, emphatically introduce the latest developments in the design of gene delivery vehicles based on biomaterials, summarize the mechanism of nucleic acid for tissue regeneration, and explore the strategies of nucleic acid delivery vehicles for various tissue regeneration. (c) 2021 Elsevier B.V. All rights reserved.
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