Journal
ACTA BIOMATERIALIA
Volume 127, Issue -, Pages 287-297Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2021.03.064
Keywords
Thiophene donor; NIR-II fluorophore probe; Single laser triggering; Molecular imaging; Photothermal; photodynamic; chemo combination therapy
Funding
- National Natural Science Foundation of China [21775166]
- Natural Science Foundation of Jiangsu Province [BK20180026, BK20151513]
- Fundamental Research Funds for the Central Universities
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Organic fluorophores/photosensitizers have limited applications in the second near-infrared (NIR-II) window due to low fluorescence quantum yields. A boron dipyrromethene (BDP) with high QYs and thiophene donor unit is created for single NIR laser-triggered phototherapeutic nanoparticles. These NPs exhibit high solubility, singlet oxygen QY, multifunctional characteristics, and high signal-to-background ratio in tumor-bearing mice.
Organic fluorophores/photosensitizers have been widely used in biological imaging and photodynamic and photothermal combination therapy in the first near-infrared (NIR-I) window. However, their applications in the second near-infrared (NIR-II) window are still limited primarily due to low fluorescence quantum yields (QYs). Here, a boron dipyrromethene (BDP) is created as a molecularly engineered thiophene donor unit with high QYs to the redshift. Thiophene insertion initiates substantial redshifts of the absorbance as compared to its counterparts in which iodine is introduced. The fluorescent molecule can be triggered by an NIR laser with a single wavelength, thereby producing emission in the NIR-II windows. Single NIR laser-triggered phototherapeutic nanoparticles (NPs) are developed by encapsulating the BDP and the chemotherapeutic drug docetaxel (DTX) by using a synthetic amphiphilic poly(styrene-co- chloromethyl styrene)-graft-poly(ethylene glycol) functionalized with folic acid (FA). These BDP-T-N-DTX-FA NPs not only show superior solubility and high singlet oxygen QY (Phi(Delta)= 62%) but also demonstrate single NIR laser-triggered multifunctional characteristics. After intravenous administration of the NPs into 4T1 tumor-bearing mice, the accumulation of the NPs in the tumor showed a high signal-to-background ratio (11.8). Furthermore, 4T1 tumors in mice were almost eradicated by DTX released from the BDP-TN-DTX-FA NPs under single NIR laser excitation and the combination of photodynamic therapy (PDT) and photothermic therapy (PTT). Statement of significance The application of organic photosensitizers is still limited primarily due to low fluorescence quantum yields (QYs) in the second near-infrared (NIR-II) window. Here, a boron dipyrromethene (BDP) as a molecularly engineered thiophene donor unit with high QYs to the redshift is created. Phototherapeutic nanoparticles (NPs) are developed by encapsulating the BDP and docetaxel (DTX) using a synthetic amphiphilic poly(styrene-co-chloromethyl styrene)-graft-poly(ethylene glycol) functionalized with folic acid (FA). These BDP-T-N-DTX-FA NPs not only show high singlet oxygen QY (Phi(Delta) = 62%) but also demonstrate single NIR laser-triggered multifunctional characteristics and a high signal-to-background ratio (11.8). Furthermore, 4T1 tumors in mice were almost eradicated by DTX released from the BDP-T-N-DTX-FA NPs under single NIR laser excitation and the PDT/PTT combination therapy. (C) 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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