4.8 Article

Protamine-Controlled Reversible DNA Packaging: A Molecular Glue

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Analysis of biomolecular condensates and protein phase separation with microfluidic technology

Miriam Linsenmeier et al.

Summary: The increasing evidence shows that membraneless organelles are essential in cellular organization, and the physico-chemical rules underlying their assembly and functions still need further exploration. Microfluidic technologies are attractive tools for analyzing biomolecular phase transitions, providing high-throughput measurements and precise control over self-assembly in time and space.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Article Biochemistry & Molecular Biology

RNA-Mediated Feedback Control of Transcriptional Condensates

Jonathan E. Henninger et al.

Summary: This study discusses the mechanisms of feedback control in regulating biological processes, especially in transcription regulation. Research indicates that RNA in transcription initiation promotes condensate formation, while RNA produced during elongation stimulates condensate dissolution. Therefore, transcriptional regulation involves a feedback mechanism where transcribed RNA both stimulates and arrests the process.
Article Multidisciplinary Sciences

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

Georg Krainer et al.

Summary: The study demonstrates that cellular proteins that form condensates at low salt concentrations can reenter a phase-separated regime at high salt concentrations, driven by hydrophobic and non-ionic interactions. This sheds light on the cooperation of hydrophobic and non-ionic interactions as general driving forces in the condensation process, with implications for biomolecular condensates.

NATURE COMMUNICATIONS (2021)

Article Chemistry, Physical

Protamine Binding Site on DNA: Molecular Dynamics Simulations and Free Energy Calculations with Full Atomistic Details

Arnab Mukherjee et al.

Summary: The research used molecular dynamics simulations to verify the optimal binding site of protamine on DNA, showing that protamine located in the major groove of DNA utilized the DNA backbone effectively. The study suggests that the binding mechanism of protamine in sperm cells is still not fully understood.

JOURNAL OF PHYSICAL CHEMISTRY B (2021)

Review Chemistry, Multidisciplinary

Use of Protamine in Nanopharmaceuticals-A Review

Ivana Ruseska et al.

Summary: Macromolecular biomolecules, such as protamine, are gaining popularity in drug delivery due to their improved targeting properties. The review focuses on mimicking protamine's natural DNA-binding and protective role to develop innovative nanopharmaceutical drug delivery systems. Additionally, it discusses the use of protamine in novel vaccine technologies, including RNA-based vaccines against infectious diseases and cancer treatment.

NANOMATERIALS (2021)

Review Biochemistry & Molecular Biology

RNA Droplets

Kevin Rhine et al.

ANNUAL REVIEW OF BIOPHYSICS, VOL 49, 2020 (2020)

Review Chemistry, Multidisciplinary

Nanotechnology for COVID-19: Therapeutics and Vaccine Research

Gaurav Chauhan et al.

ACS NANO (2020)

Article Biochemistry & Molecular Biology

Reentrant Phase Transitions and Non-Equilibrium Dynamics in Membraneless Organelles

Anthony N. Milin et al.

BIOCHEMISTRY (2018)

Review Biotechnology & Applied Microbiology

mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Review Cell Biology

Biomolecular condensates: organizers of cellular biochemistry

Salman F. Banani et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Review Chemistry, Multidisciplinary

Concentration gradient generation methods based on microfluidic systems

Xiang Wang et al.

RSC ADVANCES (2017)

Article Chemistry, Multidisciplinary

Reentrant Phase Transition Drives Dynamic Substructure Formation in Ribonucleoprotein Droplets

Priya R. Banerjee et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Chemistry, Multidisciplinary

Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles

William M. Aumiller et al.

NATURE CHEMISTRY (2016)

Article Chemistry, Physical

Aggregation dynamics of rigid polyelectrolytes

Anvy Moly Tom et al.

JOURNAL OF CHEMICAL PHYSICS (2016)

Article Multidisciplinary Sciences

A route to self-assemble suspended DNA nano-complexes

Yves Lansac et al.

SCIENTIFIC REPORTS (2016)

Article Reproductive Biology

Sperm Protamine-Status Correlates to the Fertility of Breeding Bulls

Sule Dogan et al.

BIOLOGY OF REPRODUCTION (2015)

Article Biochemical Research Methods

Cross polarization compatible dialysis chip

Micha Kornreich et al.

LAB ON A CHIP (2014)

Article Physics, Applied

Nanoscale structure of protamine/DNA complexes for gene delivery

Simona Motta et al.

APPLIED PHYSICS LETTERS (2013)

Review Biotechnology & Applied Microbiology

A novel, disruptive vaccination technology Self-adjuvanted RNActive® vaccines

Karl-Josef Kallen et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2013)

Article Biotechnology & Applied Microbiology

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

Benjamin Petsch et al.

NATURE BIOTECHNOLOGY (2012)

Article Biochemistry & Molecular Biology

Protamines: Structural Complexity, Evolution and Chromatin Patterning

Harold E. Kasinsky et al.

PROTEIN AND PEPTIDE LETTERS (2012)

Article Chemistry, Physical

Salt Effects on Condensed Protamine-DNA Assemblies: Anion Binding and Weakening of Attraction

Jason E. DeRouchey et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2011)

Article Chemistry, Physical

Salt Has a Biphasic Effect on the Higher-Order Structure of a DNA-Protamine Complex

Naoko Makita et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2011)

Article Biochemistry & Molecular Biology

Condensed DNA: Condensing the concepts

Vladimir B. Teif et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2011)

Review Chemistry, Physical

DNA compaction: fundamentals and applications

Andre Estevez-Torres et al.

SOFT MATTER (2011)

Review Pharmacology & Pharmacy

Gene delivery by lipoplexes and polyplexes

Conchita Tros de Ilarduya et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2010)

Article Biochemistry & Molecular Biology

DNA Condensed by Protamine: A Short or Long Polycation Behavior

Adriana C. Toma et al.

BIOMACROMOLECULES (2009)

Article Biochemistry & Molecular Biology

High-Pressure Freezing of Spermiogenic Nuclei Supports a Dynamic Chromatin Model for the Histone-to-Protamine Transition

Garnet Martens et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

A universal description for the experimental behavior of salt-(in)dependent oligocation-induced DNA condensation

Nikolay Korolev et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Multidisciplinary Sciences

Structure of toroidal DNA collapsed inside the phage capsid

Amelie Leforestier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Chemistry, Multidisciplinary

Expression of chirality in columnar hexagonal phases or DNA and nucleosomes

Amelie Leforestier et al.

COMPTES RENDUS CHIMIE (2008)

Article Physics, Multidisciplinary

Charge inversion accompanies DNA condensation by multivalent ions

K. Besteman et al.

NATURE PHYSICS (2007)

Article Chemistry, Physical

A coarse-grained protein-protein potential derived from an all-atom force field

Nathalie Basdevant et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2007)

Article Chemistry, Physical

Canonical sampling through velocity rescaling

Giovanni Bussi et al.

JOURNAL OF CHEMICAL PHYSICS (2007)

Review Biochemistry & Molecular Biology

Physicochemical analysis of electrostatic foundation for DNA-protein interactions in chromatin transformations

Nikolay Korolev et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2007)

Article Physics, Multidisciplinary

Salt-induced collapse and reexpansion of highly charged flexible polyelectrolytes

Pai-Yi Hsiao et al.

PHYSICAL REVIEW LETTERS (2006)

Article Physics, Multidisciplinary

Solubility and charge inversion of complexes of DNA and basic proteins

Eric Raspaud et al.

PHYSICAL REVIEW LETTERS (2006)

Review Chemistry, Multidisciplinary

GROMACS: Fast, flexible, and free

D Van der Spoel et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)

Article Andrology

DNA integrity is compromised in protamine-deficient human sperm

VW Aoki et al.

JOURNAL OF ANDROLOGY (2005)

Article Physics, Multidisciplinary

Phase diagram of solution of oppositely charged polyelectrolytes

R Zhang et al.

PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS (2005)

Article Pharmacology & Pharmacy

Albumin-protamine-oligonucleotide nanoparticles as a new antisense delivery system. Part 1: Physicochemical characterization

D Lochmann et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2005)

Article Zoology

Possible mechanisms for early and intermediate stages of sperm chromatin condensation patterning involving phase separation dynamics

LG Harrison et al.

JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY (2005)

Article Physics, Fluids & Plasmas

Phase diagram of aggregation of oppositely charged colloids in salty water

R Zhang et al.

PHYSICAL REVIEW E (2004)

Review Physics, Fluids & Plasmas

Adsorption of monovalent and multivalent cations and anions on DNA molecules -: art. no. 061903

E Allahyarov et al.

PHYSICAL REVIEW E (2003)

Article Physics, Multidisciplinary

Lamellar phase of stacked two-dimensional rafts of actin filaments

GCL Wong et al.

PHYSICAL REVIEW LETTERS (2003)

Review Physics, Multidisciplinary

Colloquium:: The physics of charge inversion in chemical and biological systems

AY Grosberg et al.

REVIEWS OF MODERN PHYSICS (2002)

Article Multidisciplinary Sciences

Cryoelectron microscopy of λ phage DNA condensates in vitreous ice:: The fine structure of DNA toroids

NV Hud et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

DNA in human and stallion spermatozoa forms local hexagonal packing with twist and many defects

NS Blanc et al.

JOURNAL OF STRUCTURAL BIOLOGY (2001)

Article Computer Science, Interdisciplinary Applications

Extension to the weighted histogram analysis method: combining umbrella sampling with free energy calculations

M Souaille et al.

COMPUTER PHYSICS COMMUNICATIONS (2001)

Article Chemistry, Physical

Reentrant condensation of DNA induced by multivalent counterions

TT Nguyen et al.

JOURNAL OF CHEMICAL PHYSICS (2000)

Article Biochemistry & Molecular Biology

Size-dependent DNA mobility in cytoplasm and nucleus

GL Lukacs et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)