4.8 Review

Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies

Related references

Note: Only part of the references are listed.
Article Medicine, Research & Experimental

Impact of anti-PEG antibody affinity on accelerated blood clearance of pegylated epoetin beta in mice

Tien-Ching Chang et al.

Summary: Antibodies that bind polyethylene glycol (PEG) can accelerate the clearance of pegylated medicines, with higher affinity antibodies leading to greater clearance and reduced drug efficacy. The molar ratio of high affinity anti-PEG antibodies to PEG-EPO correlates with accelerated blood clearance in mice.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Article Hematology

Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia

Alaeddin Khalil et al.

Summary: Concerns about the efficacy of pegylated drugs arise due to the presence of antibodies against polyethylene glycol (PEG) in healthy individuals. This study evaluated the prevalence of anti-PEG antibodies in acute lymphoblastic leukemia (ALL) patients before and/or after the first administration of pegylated E.coli asparaginase (PEG-ASNase). The results showed that pre-existing anti-PEG antibodies were detected in a considerable proportion of patients with ALL and although they did not inhibit PEG-ASNase activity, they were associated with lower serum PEG-ASNase activity levels. Patients with pre-existing antibodies may experience mild to moderate hypersensitivity reactions after their first administration of PEG-ASNase, which can be successfully addressed by re-challenge.

HAEMATOLOGICA (2022)

Review Medicine, General & Internal

Maintaining Safety with SARS-CoV-2 Vaccines

Mariana C. Castells et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Pfizer's vaccine raises allergy concerns

Jop de Vrieze

SCIENCE (2021)

Article Biotechnology & Applied Microbiology

Double attack strategy for leukemia using a pre-targeting bispecific antibody (CD20 Ab-mPEG scFv) and actively attracting PEGylated liposomal doxorubicin to enhance anti-tumor activity

Kai-Wen Ho et al.

Summary: In this study, a humanized bispecific antibody (BsAbs: CD20 Ab-mPEG scFv) was developed to target liquid tumors, enhancing therapeutic efficacy by improving cancer cellular internalization. The combination of CD20 Ab-mPEG scFv and PEGylated liposomal doxorubicin led to a ninefold increase in tumor cytotoxicity compared to other antibodies in vitro. These results demonstrate the potential of this double-attack strategy in improving therapeutic efficacy for liquid tumors.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Chemistry, Multidisciplinary

Replacement of L-amino acid peptides with D-amino acid peptides mitigates anti-PEG antibody generation against polymer-peptide conjugates in mice

Meilyn Sylvestre et al.

Summary: This study investigated the toxicity issues of the VIPER polymer platform after repeat injections, successfully mitigating the generation of anti-PEG antibodies by substituting amino acid enantiomers, and demonstrating the good tolerability of D-amino acid polymer-peptide conjugates in vivo.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Biochemistry & Molecular Biology

Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures

David Sehnal et al.

Summary: Large biomolecular structures are being determined experimentally using established techniques such as crystallography and electron microscopy, with performance requirements for visualization and analysis tools increasing rapidly. The Mol* Viewer is an advanced online web-native 3D visualization tool that allows visualization of complex structures, and is the primary tool used by PDBe and RCSB PDB.

NUCLEIC ACIDS RESEARCH (2021)

Article Cell Biology

Clearance of pegylated interferon by Kupffer cells limits NK cell activation and therapy response of patients with HBV infection

Akira Nishio et al.

Summary: The study found that early NK cell activation in patients with chronic HBV infection is associated with better treatment outcomes, while delayed increases in PEG-IFN-alpha concentration may lead to impaired immune responses. These results reveal the important role of PEG-IFN-alpha in treatment, with its immunomodulatory functions being affected by pharmacokinetics.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Letter Allergy

Anti-PEG IgE in anaphylaxis associated with polyethylene glycol

Zhao-Hua Zhou et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

Review Pharmacology & Pharmacy

Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals

Gergely Tibor Kozma et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Review Pharmacology & Pharmacy

Liposomal Irinotecan: A Review in Metastatic Pancreatic Adenocarcinoma

James E. Frampton

DRUGS (2020)

Article Medicine, Research & Experimental

Impact of Pre-Existing or Induced Anti-PEG IgM on the Pharmacokinetics of Peginterferon Alfa-2a (Pegasys) in Mice

Nehal E. Elsadek et al.

MOLECULAR PHARMACEUTICS (2020)

Article Chemistry, Multidisciplinary

Structure of an anti-PEG antibody reveals an open ring that captures highly flexible PEG polymers

Justin T. Huckaby et al.

COMMUNICATIONS CHEMISTRY (2020)

Article Cell Biology

Structural basis of polyethylene glycol recognition by antibody

Cheng-Chung Lee et al.

JOURNAL OF BIOMEDICAL SCIENCE (2020)

Review Biochemistry & Molecular Biology

B Cell Responses: Cell Interaction Dynamics and Decisions

Jason G. Cyster et al.

Review Pharmacology & Pharmacy

The Interplay Between Blood Proteins, Complement, and Macrophages on Nanomedicine Performance and Responses

S. Moein Moghimi et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

Review Materials Science, Multidisciplinary

PEGylated liposomes: immunological responses

Marwa Mohamed et al.

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS (2019)

Article Nanoscience & Nanotechnology

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc et al.

NATURE NANOTECHNOLOGY (2019)

Article Allergy

Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized

Cosby A. Stone et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

Article Medicine, Research & Experimental

Physician Awareness of Immune Responses to Polyethylene Glycol-Drug Conjugates

Morgan D. McSweeney et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2018)

Article Pharmacology & Pharmacy

A hydroxyl PEG version of PEGylated liposomes and its impact on anti-PEG IgM induction and on the accelerated clearance of PEGylated liposomes

Taro Shimizu et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)

Article Biochemistry & Molecular Biology

Understanding the Role of Anti-PEG Antibodies in the Complement Activation by Doxil in Vitro

Barry W. Neun et al.

MOLECULES (2018)

Editorial Material Biotechnology & Applied Microbiology

Translational gaps in animal models of human infusion reactions to nanomedicines

S. Moein Moghimi et al.

NANOMEDICINE (2018)

News Item Biotechnology & Applied Microbiology

Alnylam launches era of RNAi drugs

Ken Garber

NATURE BIOTECHNOLOGY (2018)

Article Transplantation

C-C motif-ligand 2 inhibition with emapticap pegol ( NOX-E36) in type 2 diabetic patients with albuminuria

Jan Menne et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2017)

Article Allergy

The pathophysiology of anaphylaxis

Laurent L. Reber et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Review Immunology

A Hard(y) Look at B-1 Cell Development and Function

Nicole Baumgarth

JOURNAL OF IMMUNOLOGY (2017)

Review Biotechnology & Applied Microbiology

FDA-Approved Oligonucleotide Therapies in 2017

Cy A. Stein et al.

MOLECULAR THERAPY (2017)

Article Medicine, Research & Experimental

Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo

Xi Zhu et al.

THERANOSTICS (2017)

Article Materials Science, Biomaterials

Cross-Reactivity of Select PEG-Binding Antibodies to Other Polymers Containing a C-C-O Backbone

Justin McCallen et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2017)

Article Materials Science, Biomaterials

Cross-Reactivity of Select PEG-Binding Antibodies to Other Polymers Containing a C-C-O Backbone

Justin McCallen et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2017)

Article Engineering, Biomedical

Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus

Christine E. Henry et al.

ACTA BIOMATERIALIA (2016)

Review Pharmacology & Pharmacy

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

Jung Soo Suk et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Article Chemistry, Analytical

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

Bing-Mae Chen et al.

ANALYTICAL CHEMISTRY (2016)

Review Immunology

Follicular Helper T Cells

Carola G. Vinuesa et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 34 (2016)

Review Allergy

Immediate-type hypersensitivity to polyethylene glycols: a review

E. Wenande et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2016)

Review Pharmacology & Pharmacy

Peginesatide for the treatment of anemia due to chronic kidney disease - an unfulfilled promise

Terhi Hermanson et al.

EXPERT OPINION ON DRUG SAFETY (2016)

Review Immunology

Germinal Center B Cell Dynamics

Luka Mesin et al.

IMMUNITY (2016)

Article Chemistry, Multidisciplinary

Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation

Peng Zhang et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Article Medicine, General & Internal

A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A

F. Peyvandi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Chemistry, Multidisciplinary

The Mystery of Antibodies Against Polyethylene Glycol (PEG) - What do we Know?

Christian Lubich et al.

PHARMACEUTICAL RESEARCH (2016)

Article Cell Biology

Reloadable multidrug capturing delivery system for targeted ischemic disease treatment

Jasmine P. J. Wu et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Article Biochemistry & Molecular Biology

2′Fluoro Modification Differentially Modulates the Ability of RNAs to Activate Pattern Recognition Receptors

Youngju Lee et al.

NUCLEIC ACID THERAPEUTICS (2016)

Article Oncology

Selective Delivery of PEGylated Compounds to Tumor Cells by Anti-PEG Hybrid Antibodies

Hsin-Yi Tung et al.

MOLECULAR CANCER THERAPEUTICS (2015)

Article Medicine, Research & Experimental

Anti-PEG IgM Is a Major Contributor to the Accelerated Blood Clearance of Polyethylene Glycol-Conjugated Protein

Yu Mima et al.

MOLECULAR PHARMACEUTICS (2015)

Article Multidisciplinary Sciences

T cell help controls the speed of the cell cycle in germinal center B cells

Alexander D. Gitlin et al.

SCIENCE (2015)

Review Nanoscience & Nanotechnology

Anti-PEG immunity: emergence, characteristics, and unaddressed questions

Qi Yang et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2015)

Article Gastroenterology & Hepatology

Anaphylactic Shock Caused by Ingestion of Polyethylene Glycol

Sun Hee Lee et al.

INTESTINAL RESEARCH (2015)

Review Pharmacology & Pharmacy

Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics

Johan J. F. Verhoef et al.

DRUG DISCOVERY TODAY (2014)

Article Biochemistry & Molecular Biology

Activation of TLR9 by incorporated pDNA within PEG-coated lipoplex enhances anti-PEG IgM production

Y. Hashimoto et al.

GENE THERAPY (2014)

Article Pharmacology & Pharmacy

Influence of dose and animal species on accelerated blood clearance of PEGylated liposomal doxorubicin

Takuya Suzuki et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

Article Biochemistry & Molecular Biology

Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins

Mark G. P. Saifer et al.

MOLECULAR IMMUNOLOGY (2014)

Letter Medicine, General & Internal

Anaphylaxis and Hypotension after Administration of Peginesatide

Charles L. Bennett et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Multidisciplinary Sciences

Removing T-cell epitopes with computational protein design

Chris King et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

Christoph A. Diebolder et al.

SCIENCE (2014)

Review Biochemistry & Molecular Biology

The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity

Fabien B. Vincent et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2013)

Article Pharmacology & Pharmacy

Abrogation of the accelerated blood clearance phenomenon by SOXL regimen: Promise for clinical application

Ai Nagao et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

Article Pharmacology & Pharmacy

Hypersensitivity to Polyethylene Glycols

Sapna Shah et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2013)

Article Chemistry, Multidisciplinary

Hydrophobic blocks of PEG-conjugates play a significant role in the accelerated blood clearance (ABC) phenomenon

Kouichi Shiraishi et al.

JOURNAL OF CONTROLLED RELEASE (2013)

Review Immunology

Innate B cell helpers reveal novel types of antibody responses

Carola G. Vinuesa et al.

NATURE IMMUNOLOGY (2013)

Article Medicine, General & Internal

Factor VIII Products and Inhibitor Development in Severe Hemophilia A

Samantha C. Gouw et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Multidisciplinary Sciences

Potential Capacity of Aptamers to Trigger Immune Activation in Human Blood

Meltem Avci-Adali et al.

PLOS ONE (2013)

Article Biochemistry & Molecular Biology

PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins

Martin Schlapschy et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2013)

Review Immunology

Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes

Andrea Cerutti et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Review Hematology

Factor VIII inhibitors in hemophilia A: rationale and latest evidence

Char Witmer et al.

THERAPEUTIC ADVANCES IN HEMATOLOGY (2013)

Review Pharmacology & Pharmacy

Chemistry for peptide and protein PEGylation

M. J. Roberts et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

Review Biochemical Research Methods

Analytical Measurement of PEGylated Molecules

Tian-Lu Cheng et al.

BIOCONJUGATE CHEMISTRY (2012)

Article Biochemical Research Methods

Role of the Methoxy Group in Immune Responses to mPEG-Protein Conjugates

Merry R. Sherman et al.

BIOCONJUGATE CHEMISTRY (2012)

Review Biochemistry & Molecular Biology

IgM memory B cells: a mouse/human paradox

Claude-Agnes Reynaud et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

Review Medicine, Research & Experimental

Fc-fusion proteins: new developments and future perspectives

Daniel M. Czajkowsky et al.

EMBO MOLECULAR MEDICINE (2012)

Article Pharmacology & Pharmacy

A frustrating problem: Accelerated blood clearance of PEGylated solid lipid nanoparticles following subcutaneous injection in rats

Yongxue Zhao et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2012)

Review Immunology

The tick-over theory revisited: Is C3 a contact-activated protein?

Bo Nilsson et al.

IMMUNOBIOLOGY (2012)

Article Pharmacology & Pharmacy

Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles

Hiroyuki Koide et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

Article Pharmacology & Pharmacy

Accelerated blood clearance of PEGylated liposomes containing doxorubicin upon repeated administration to dogs

Takuya Suzuki et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

Review Chemistry, Multidisciplinary

Doxil® - The first FDA-approved nano-drug: Lessons learned

Yechezkel (Chezy) Barenholz

JOURNAL OF CONTROLLED RELEASE (2012)

Article Nanoscience & Nanotechnology

Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisome

Janos Szebeni et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2012)

Article Biochemistry & Molecular Biology

A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model

Takehisa Kitazawa et al.

NATURE MEDICINE (2012)

Article Chemistry, Medicinal

Differences in Colloidal Structure of PEGylated Nanomaterials Dictate the Likelihood of Accelerated Blood Clearance

Lisa M. Kaminskas et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2011)

Review Medicine, General & Internal

A Rare Case of Anaphylaxis to Bowel Prep: A Case Report and Review of the Literature

Julia A. Savitz et al.

MILITARY MEDICINE (2011)

Review Biotechnology & Applied Microbiology

Nanoparticle PEGylation for imaging and therapy

Jesse V. Jokerst et al.

NANOMEDICINE (2011)

Article Multidisciplinary Sciences

Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift

Jason R. Cantor et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Pharmacology & Pharmacy

A double antigen bridging immunogenicity ELISA for the detection of antibodies to polyethylene glycol polymers

Yijuan Liu et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2011)

Article Radiology, Nuclear Medicine & Medical Imaging

Development of a Universal Anti-Polyethylene Glycol Reporter Gene for Noninvasive Imaging of PEGylated Probes

Kuo-Hsiang Chuang et al.

JOURNAL OF NUCLEAR MEDICINE (2010)

Article Pharmacology & Pharmacy

Repeated injection of pegylated liposomal antitumour drugs induces the disappearance of the rapid distribution phase

JingXia Cui et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2010)

Review Chemistry, Multidisciplinary

Poly(2-oxazoline)s: A Polymer Class with Numerous Potential Applications

Richard Hoogenboom

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

Article Chemistry, Medicinal

Oligodeoxyribonucleotide-Based Antagonists for Toll-Like Receptors 7 and 9

Daqing Wang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2009)

Article Biotechnology & Applied Microbiology

A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

Volker Schellenberger et al.

NATURE BIOTECHNOLOGY (2009)

Article Chemistry, Multidisciplinary

Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles

Tsutomu Ishihara et al.

PHARMACEUTICAL RESEARCH (2009)

Review Immunology

Cracking the BAFF code

Fabienne Mackay et al.

NATURE REVIEWS IMMUNOLOGY (2009)

Review Immunology

Mechanism and regulation of class switch recombination

Janet Stavnezer et al.

ANNUAL REVIEW OF IMMUNOLOGY (2008)

Review Biotechnology & Applied Microbiology

Overcoming the innate immune response to small interfering RNA

Adam Judge et al.

HUMAN GENE THERAPY (2008)

Article Pharmacology & Pharmacy

Particle size-dependent triggering of accelerated blood clearance phenomenon

Hiroyuki Koide et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)

Review Chemistry, Multidisciplinary

Sheddable coatings for long-circulating nanoparticles

Birgit Romberg et al.

PHARMACEUTICAL RESEARCH (2008)

Article Biotechnology & Applied Microbiology

Size comparison between proteins PEGylated with branched and linear Poly(Ethylene glycol) molecules

Conan J. Fee

BIOTECHNOLOGY AND BIOENGINEERING (2007)

Article Immunology

Specific TLR ligands regulate APRIL secretion by dendritic cells in a PKR-dependent manner

Gijs Hardenberg et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2007)

Review Immunology

Germinal-center organization and cellular dynamics

Christopher D. C. Allen et al.

IMMUNITY (2007)

Review Allergy

Anaphylaxis: Lessons from mouse models

Fred D. Finkelman

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)

Article Chemistry, Multidisciplinary

Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes

Tatsuhiro Ishida et al.

JOURNAL OF CONTROLLED RELEASE (2006)

Review Biotechnology & Applied Microbiology

Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

EWM Ng et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Article Biotechnology & Applied Microbiology

Hypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomes

A Judge et al.

MOLECULAR THERAPY (2006)

Review Pharmacology & Pharmacy

PEGylation, successful approach to drug delivery

FM Veronese et al.

DRUG DISCOVERY TODAY (2005)

Article Biotechnology & Applied Microbiology

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

AD Judge et al.

NATURE BIOTECHNOLOGY (2005)

Article Pharmacology & Pharmacy

Immunogenicity and rapid blood clearance of liposomes containing polyethylene glycol-lipid conjugates and nucleic acid

SC Semple et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)

Article Immunology

TACI and BAFF-R mediate isotype switching in B cells

E Castigli et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

Article Clinical Neurology

Immunogenicity of interferon beta: differences among products

A Bertolotto et al.

JOURNAL OF NEUROLOGY (2004)

Article Hematology

Environmental and genetic factors influencing inhibitor development

J Oldenburg et al.

SEMINARS IN HEMATOLOGY (2004)

Review Pharmacology & Pharmacy

Immunogenicity of therapeutic proteins: Clinical implications and future prospects

H Schellekens

CLINICAL THERAPEUTICS (2002)

Review Biotechnology & Applied Microbiology

Bioequivalence and the immunogenicity of biopharmaceuticals

H Schellekens

NATURE REVIEWS DRUG DISCOVERY (2002)

Review Immunology

Marginal-zone B cells

F Martin et al.

NATURE REVIEWS IMMUNOLOGY (2002)

Article Pharmacology & Pharmacy

Pegylated interferon-α2b:: Pharmacokinetics, pharmacodynamics, safety, and preliminary efficacy data

P Glue et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2000)

Article Biochemistry & Molecular Biology

Doxorubicin entrapped within liposome-associated antigens results in a selective inhibition of the antibody response to the linked antigen

C Oja et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2000)

Article Oncology

Comparison of in vitro antibody-targeted cytotoxicity using mouse, rat and human effectors

I Bergman et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2000)

Article Biochemistry & Molecular Biology

B cells extract and present immobilized antigen: implications for affinity discrimination

FD Batista et al.

EMBO JOURNAL (2000)