Journal
ACS NANO
Volume 15, Issue 6, Pages 9827-9840Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.1c00746
Keywords
hierarchical helical arrays; chirality; enantioselectivity; chiroptics; catalysis
Categories
Funding
- National Natural Science Foundation of China [21621004, 51773149, 22078239]
- Tianjin Development Program for Innovation and Entrepreneurship (2018)
- State Key Laboratory of Chemical Engineering [SKL-ChE-20Z04]
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This study reports the self-templated assembly of amyloid-like dipeptides into long-range-ordered hierarchical helical arrays through spontaneous fibrillization and hierarchical helical assembly within a confined film. By changing the chirality and enantioselective interactions, researchers can precisely control the phase behavior, handedness, and chiroptics of the self-assembled HHAs. The redox activity of HHAs allows for the in situ decoration of nanoparticles with high catalytic activity.
Chiral self-assembly of peptides has attracted great interest owing to their promising applications in biomedicine, chemistry, and materials science. However, compared with the rich knowledge about their chiral self-assembly at the molecular or nanoscale, the formation of long-range-ordered hierarchical helical arrays (HHAs) from simple peptides remains a formidable challenge. Herein, we report the self-templated assembly of an amyloid-like dipeptide into long-range-ordered HHAs by their spontaneous fibrillization and hierarchical helical assembly within a confined film. The chiral interactions between the peptide and diamines result in geometry frustration and the phase transition of self-assembling peptide films from achiral spherulite structures into chiral HHAs. By changing the chirality and enantioselective interactions, we can control the phase behavior, handedness, and chiroptics of the self-assembled HHAs precisely. Moreover, the redox activity of the HHAs allows the in situ decoration of nanoparticles with high catalytic activity. These results provide insights into the chiral self-assembly of peptides and the fabrication of highly ordered materials with complex architectures and promising applications in chiroptics and catalysis.
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