☆ 4.6 Review

The D614G Virus Mutation Enhances Anosmia in COVID-19 Patients: Evidence from a Systematic Review and Meta-analysis of Studies from South Asia

ACS CHEMICAL NEUROSCIENCE (2021)

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Summary: Olfactory dysfunction is common in patients with COVID-19, including those who are asymptomatic. However, the Butanol Threshold Test was not able to differentiate between asymptomatic Covid 19 patients and controls.

INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY (2021)

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Article Biochemistry & Molecular Biology

Functional importance of the D614G mutation in the SARS-CoV-2 spike protein

Cody B. Jackson et al.

Summary: The D614G spike mutation in SARS-CoV-2 virus leads to more efficient infection of cells and animals, without affecting the affinity of the S protein for ACE2. This mutation is significant in the current global pandemic.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Otorhinolaryngology

Olfactory taste disorder as a presenting symptom of COVID-19: a large single-center Singapore study

Alex C. Tham et al.

Summary: The study aimed to investigate the prevalence and epidemiological risk factors of olfactory and/or taste disorder (OTD), particularly isolated OTD, in patients with laboratory-confirmed COVID-19 infection. A total of 1065 patients were recruited, with 12.6% having OTD and 1.1% having isolated OTD. Female gender, presence of blocked nose, and absence of fever were significantly associated with OTD.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2021)

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Article Surgery

Testing Olfactory and Gustatory Dysfunctions among Quarantine COVID-19 Suspects

Vijay Bidkar et al.

Summary: This study aimed to investigate the association between loss of smell and taste with COVID-19 positivity. The results showed that a higher percentage of confirmed COVID-19 cases had olfactory and gustatory dysfunction compared to negative subjects. Testing for these sensory losses had higher sensitivity in identifying recent-onset loss of sensations in COVID-19 cases, making it a potentially simple and cost-effective screening test.

INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY (2021)

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Article Surgery

Otolaryngologic Manifestation and Long-Term Outcome in Mild COVID-19: Experience from a Tertiary Care Centre in India

Smriti Panda et al.

Summary: This study aimed to comprehensively study the spectrum of ENT manifestations in mild and asymptomatic COVID-19 and observe the natural course of anosmia and dysgeusia following SARS-Cov-2 infection. Results showed that smell and taste disturbances accounted for a significant proportion of ENT symptoms, with gradual recovery rates increasing over time, reaching nearly complete recovery by 4 weeks.

INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY (2021)

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Article Pharmacology & Pharmacy

The incidence of anosmia in patients with laboratory-confirmed COVID 19 infection in India: An observational study

Vinod Kumar et al.

Summary: The study revealed that approximately 30% of COVID-19 patients experience anosmia, with an average duration of about 7.8 days. Most patients recover from anosmia and other symptoms within 2 weeks. Anosmia is significantly associated with ageusia, and eosinophil count plays a role in anosmic patients.

JOURNAL OF ANAESTHESIOLOGY CLINICAL PHARMACOLOGY (2021)

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Letter Cell Biology

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

Yanan Cao et al.

CELL DISCOVERY (2020)

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Article Pharmacology & Pharmacy

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furinlike cleavage site absent in CoV of the same clade

B. Coutard et al.

ANTIVIRAL RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

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Article Otorhinolaryngology

The role of self-reported smell and taste disorders in suspected COVID-19

Athanasia Printza et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2020)

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Letter Otorhinolaryngology

The role of self-reported olfactory and gustatory dysfunction as a screening criterion for suspected COVID-19

Liang En Wee et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2020)

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Article Otorhinolaryngology

Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study

Jerome R. Lechien et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2020)

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Article Multidisciplinary Sciences

Cell entry mechanisms of SARS-CoV-2

Jian Shang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Otorhinolaryngology

Early recovery following new onset anosmia during the COVID-19 pandemic - an observational cohort study

Claire Hopkins et al.

JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY (2020)

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Article Medicine, General & Internal

Spread of SARS-CoV-2 in the Icelandic Population

Daniel F. Gudbjartsson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Proinflammatory Cytokines in the Olfactory Mucosa Result in COVID-19 Induced Anosmia

Abolfazl Torabi et al.

ACS CHEMICAL NEUROSCIENCE (2020)

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Review Otorhinolaryngology

The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis

Jane Y. Tong et al.

OTOLARYNGOLOGY-HEAD AND NECK SURGERY (2020)

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Article Cell Biology

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy

Rosanna Asselta et al.

AGING-US (2020)

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Article Immunology

Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters

Bertrand Bryche et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

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Article Biochemistry & Molecular Biology

Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding

Tyler N. Starr et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Bette Korber et al.

CELL (2020)

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Article Genetics & Heredity

Analysis of ACE2 Genetic Variability among Populations Highlights a Possible Link with COVID-19-Related Neurological Complications

Claudia Strafella et al.

GENES (2020)

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Article Medicine, General & Internal

A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe

Alberto M. Borobia et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Immunology

Olfactory Dysfunction in Coronavirus Disease 2019 Patients: Observational Cohort Study and Systematic Review

Tom Wai-Hin Chung et al.

OPEN FORUM INFECTIOUS DISEASES (2020)

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Article Chemistry, Multidisciplinary

Atomistic simulation reveals structural mechanisms underlyingD614Gspike glycoprotein-enhanced fitness inSARS-COV-2

I. Olaposi Omotuyi et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2020)

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Review Biochemistry & Molecular Biology

Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences

Christopher S. von Bartheld et al.

ACS CHEMICAL NEUROSCIENCE (2020)

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Editorial Material Biochemistry & Molecular Biology

Chemosensory Dysfunction in COVID-19: Integration of Genetic and Epidemiological Data Points to D614G Spike Protein Variant as a Contributing Factor

Rafal Butowt et al.

ACS CHEMICAL NEUROSCIENCE (2020)

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Review Otorhinolaryngology

COVID-19 and anosmia: A review based on up-to-date knowledge

Xiangming Meng et al.

AMERICAN JOURNAL OF OTOLARYNGOLOGY (2020)

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Letter Infectious Diseases

Viral dynamics in mild and severe cases of COVID-19

Yang Liu et al.

LANCET INFECTIOUS DISEASES (2020)

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Letter Medicine, Research & Experimental

In Reference to Anosmia and Ageusia: Common Findings in COVID-19 Patients

Pranav Ish et al.

LARYNGOSCOPE (2020)

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Review Medicine, General & Internal

Smell and Taste Dysfunction in Patients With COVID-19: A Systematic Review and Meta-analysis

Akosua Adom Agyeman et al.

MAYO CLINIC PROCEEDINGS (2020)

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Article Biochemistry & Molecular Biology

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

Leonid Yurkovetskiy et al.

CELL (2020)

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Review Behavioral Sciences

Objective Sensory Testing Methods Reveal a Higher Prevalence of Olfactory Loss in COVID-19-Positive Patients Compared to Subjective Methods: A Systematic Review and Meta-Analysis

Mackenzie E. Hannum et al.

CHEMICAL SENSES (2020)

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Review Neurosciences

COVID-19 and the Chemical Senses: Supporting Players Take Center Stage

Keiland W. Cooper et al.

NEURON (2020)

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Article Otorhinolaryngology

Olfactory and Gustatory Dysfunction as an Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study

Chenghao Qiu et al.

OTOLARYNGOLOGY-HEAD AND NECK SURGERY (2020)

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Review Allergy

Frequency and Clinical Utility of Olfactory Dysfunction in COVID-19: a Systematic Review and Meta-analysis

Khang Wen Pang et al.

CURRENT ALLERGY AND ASTHMA REPORTS (2020)

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Letter Respiratory System

Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication

Mengfei Chen et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Editorial Material Virology

The D614G substitution in the S gene and clinical information for patients with COVID-19 detected in Hong Kong

Gannon C. K. Mak et al.

JOURNAL OF CLINICAL VIROLOGY (2020)

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Review Otorhinolaryngology

Olfactory disorders in coronavirus disease 2019 patients: a systematic literature review

E. Fuccillo et al.

JOURNAL OF LARYNGOLOGY AND OTOLOGY (2020)

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Article Medicine, Research & Experimental

COVID-19 Viral Load in the Severity of and Recovery From Olfactory and Gustatory Dysfunction

Ryan H. W. Cho et al.

LARYNGOSCOPE (2020)

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Article Multidisciplinary Sciences

Neuropilin-1 is a host factor for SARS-CoV-2 infection

James L. Daly et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Ludovico Cantuti-Castelvetri et al.

SCIENCE (2020)

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Editorial Material Chemistry, Medicinal

Structural Impact of Mutation D614G in SARS-CoV-2 Spike Protein: Enhanced Infectivity and Therapeutic Opportunity

Ariel Fernandez

ACS MEDICINAL CHEMISTRY LETTERS (2020)

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Article Clinical Neurology

Anosmia is associated with lower in-hospital mortality in COVID-19

Blanca Talavera et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2020)

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Article Multidisciplinary Sciences

Genomic epidemiology reveals multiple introductions and spread of SARS-CoV-2 in the Indian state of Karnataka

Chitra Pattabiraman et al.

PLOS ONE (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

Lizhou Zhang et al.

NATURE COMMUNICATIONS (2020)

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Article Microbiology

Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity

Sunil Raghav et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Article Medicine, General & Internal

The Association of “Loss of Smell” to COVID-19: A Systematic Review and Meta-Analysis

Muhammad Aziz et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2020)

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Article Medicine, General & Internal

Quantitative assessment of olfactory dysfunction accurately detects asymptomatic COVID-19 carriers

Anindya S. Bhattacharjee et al.

ECLINICALMEDICINE (2020)

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Article Otorhinolaryngology

Olfactory and taste dysfunction in coronavirus disease 2019 patients: its prevalence and outcomes

A. Jain et al.

JOURNAL OF LARYNGOLOGY AND OTOLOGY (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

Yixuan J. Hou et al.

SCIENCE (2020)

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Article Genetics & Heredity

Self-Reported Symptoms of COVID-19, Including Symptoms Most Predictive of SARS-CoV-2 Infection, Are Heritable

Frances M. K. Williams et al.

TWIN RESEARCH AND HUMAN GENETICS (2020)

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Article Medicine, General & Internal

Symptomatology and Epidemiologic Characteristics of COVID 19 Patients in Kerala, India

Betsy Varghese et al.

JOURNAL OF EVOLUTION OF MEDICAL AND DENTAL SCIENCES-JEMDS (2020)

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Review Immunology

On the genetics and immunopathogenesis of COVID-19

Chaim Oscar Jacob

CLINICAL IMMUNOLOGY (2020)

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Article Medicine, General & Internal

Characteristics, risk factors and outcomes among the first consecutive 1096 patients diagnosed with COVID-19 in Kuwait

Sulaiman Almazeedi et al.

ECLINICALMEDICINE (2020)

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Article Medicine, General & Internal

The Frequency of Neurological Symptoms in COVID-19 Patients at a Tertiary Care Hospital in Pakistan

Aamir Makda et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2020)

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Article Medicine, General & Internal

Clinical Presentation, Management and In-Hospital Outcome of Healthcare Personnel With COVID-19 Disease

Fazila-Tun-Nesa Malik et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2020)

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Article Medicine, General & Internal

Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients

Yonghyun Lee et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2020)

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Article Surgery

Prevalence of New Onset Anosmia in COVID-19 Patients: Is The Trend Different Between European and Indian Population?

Prasun Mishra et al.

INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY (2020)

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Article Medicine, General & Internal

Frequency of Neurological Presentations of Coronavirus Disease in Patients Presenting to a Tertiary Care Hospital During the 2019 Coronavirus Disease Pandemic

Samar Iltaf et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2020)

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Review Medicine, General & Internal

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

David Moher et al.

PLOS MEDICINE (2009)

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Article Mathematical & Computational Biology

Quantifying heterogeneity in a meta-analysis

JPT Higgins et al.

STATISTICS IN MEDICINE (2002)

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