Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 35, Pages 41464-41472Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c12235
Keywords
copper sulfide nanoparticles; glucose oxidase; Fenton reaction; cancer therapy; starvation therapy
Funding
- China Postdoctoral Science Foundation [2019M653139, 2019M653979]
- Guangdong Province Higher Vocational College and Schools Pearl River Scholar Funded Scheme
- Canada Research Chairs Program, New Frontiers in Research Fund-Exploration [NFRFE-2018-01005]
- Project of Scientific and Technological Foundation of Shenzhen, China [GJHZ20180928161212140]
- Cape Breton University RISE program
- NSERC Discovery Grants Program
- Canada's Telus Ride for Dad (RFD)
- The Prostate Cancer Fight Foundation (PCFF)
- Post-doctoral Foundation Project of Shenzhen Polytechnic [6019330001K, 6019330006K, 6019330007K]
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A simple formulation of glucose-oxidase-coated CuS nanoparticles has shown high effectiveness in melanoma treatment, utilizing a synergistic combination of glucose starvation, photothermal therapy, and advanced chemodynamic therapy enabled by near-infrared irradiation coupled with Fenton-like reactions enhanced by endogenous chloride.
Multimodal nanotherapeutic cancer treatments are widely studied but are often limited by their costly and complex syntheses that are not easily scaled up. Herein, a simple formulation of glucose-oxidasecoated CuS nanoparticles was demonstrated to be highly effective for melanoma treatment, acting through a synergistic combination of glucose starvation, photothermal therapy, and synergistic advanced chemodynamic therapy enabled by near-infrared irradiation coupled with Fenton-like reactions that were enhanced by endogenous chloride.
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