Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 24, Pages 28764-28773Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c04895
Keywords
NaCa2HSi3O9; nanorods; pectolite coatings; collagen I; antimicrobial peptide; drug eluting coatings; cytocompatibility
Funding
- National Natural Science Foundation of China [51971171, 51631007]
- National Key Research and Development Program of China [2016YFC1100600, 2016YFC1100604]
- Natural Science Basic Research Program of Shaanxi Province [2020JM-024]
- NIH [AI AI134770]
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Titanium is commonly used in medical implants due to its mechanical strength and biocompatibility. Recent studies have focused on developing coatings to enhance the properties of Ti implants, with Ca- and Si-based ceramic coatings being able to release ions to improve bone integration. However, the high degradation rates of these ceramics may reduce cell viability, requiring the use of polymeric or protein-based coatings to modulate degradation while maintaining stability and biocompatibility.
Titanium is widely utilized for manufacturing medical implants due to its inherent mechanical strength and biocompatibility. Recent studies have focused on developing coatings to impart unique properties to Ti implants, such as antimicrobial behavior, enhanced cell adhesion, and osteointegration. Ca- and Si-based ceramic (CS) coatings can enhance bone integration through the release of Ca and Si ions. However, high degradation rates of CS ceramics create a basic environment that reduces cell viability. Polymeric or protein-based coatings may be employed to modulate CS degradation. However, it is challenging to ensure coating stability over extended periods of time without compromising biocompatibility. In this study, we employed a fluorous-cured collagen shell as a drug-loadable scaffold around CS nanorod coatings on Ti implants. Fluorous-cured collagen coatings have enhanced mechanical and enzymatic stability and are able to regulate the release of Ca and Si ions. Furthermore, the collagen scaffold was loaded with antimicrobial peptides to impart antimicrobial activity while promoting cell adhesion. These multifunctional collagen coatings simultaneously regulate the degradation of CS ceramics and enhance antimicrobial activity, while maintaining biocompatibility.
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