Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 23, Pages 26770-26781Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c05514
Keywords
diabetic foot ulcers; hydrogel; wound dressing; epsilon-polylysine; tissue adhesive; extensive temperature tolerance
Funding
- National Nature Science Foundation of China [51861145311, 51373061]
- Interdisciplinary Innovation Project of the First Hospital of Jilin University [JDYYJCHX2020005]
- Achievement Transformation Project of the First Hospital of Jilin University [JDYYZH-2102048, 2102050]
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This study developed a temperature-tolerant antibacterial hydrogel dressing with excellent properties, effectively promoting the healing of diabetic foot ulcers (DFUs).
Diabetic foot ulcers (DFUs) are hard-healing chronic wounds and susceptible to bacterial infection. Conventional hydrogel dressings easily lose water at high temperature or freeze at low temperature, making them unsuitable for long-term use or in extreme environments. Herein, a temperature-tolerant (-20 to 60 degrees C) antibacterial hydrogel dressing is fabricated by the assembly of polyacrylamide, gelatin, and epsilon-polylysine. Owing to the water/glycerin (Gly) binary solvent system, the resultant hydrogel (G-PAGL) displayed good heat resistance and antifreezing properties. Within the wide temperature range (-20 to 60 degrees C), all the desirable features of the hydrogel, including super-stretchability (>1400%), enduring water retention, adhesiveness, and persistent antibacterial property, are quite stable. Remarkably, the hydrogel wound dressing displayed lasting and broad antibacterial activity against Gram-positive and Gram-negative bacteria. Satisfactorily, the double-network (DN) G-PAGL hydrogel dressing could effectively promote the healing of DFUs by accelerating collagen deposition, promoting angiogenesis, and inhibiting bacterial breed. As far as we know, this is the first time that the extensive temperature-tolerant DN hydrogel with antibacterial ability is developed to use as DFU wound dressing. The G-PAGL hydrogel provides more choices for DFU wound dressings that could be used in extreme environments.
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