Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 30, Pages 35365-35375Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c08076
Keywords
heteroatom-doped carbon dots; two-photon imaging probe; photodynamic-photothermal effects; synergistic phototherapy; tumor
Funding
- National Natural Science Foundation of China [21765003, 201874030]
- Natural Science Foundation of Guangxi Province [2017GXNSFFA198014]
- BAGUI Scholar Program
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The study presents S and N atom co-doped carbon dots (S,N-CDs) for tumor phototherapy, which exhibit two-photon emission and high photothermal conversion efficiency. S,N-CDs show higher therapeutic efficiency compared to N-doped CDs, highlighting their potential as an effective therapeutic agent for tumor treatment.
Phototherapy exhibits significant potential as a novel tumor treatment method, and the development of highly active photosensitizers and photothermal agents has drawn considerable attention. In this work, S and N atom co-doped carbon dots (S,N-CDs) with an absorption redshift effect were prepared by hydrothermal synthesis with lysine, o-phenylenediamine, and sulfuric acid as raw materials. The near-infrared (NIR) absorption features of the S,N-CDs resulted in two-photon (TP) emission, which has been used in TP fluorescence imaging of lysosomes and tumor tissue pH and real-time monitoring of apoptosis during tumor phototherapy, respectively. The obtained heteroatom co-doped CDs can be used not only as an NIR imaging probe but also as an effective photodynamic therapy/photothermal therapy (PDT/PTT) therapeutic agent. The efficiencies of different heteroatom-doped CDs in tumor treatment were compared. It was found that the S,N-CDs showed higher therapeutic efficiency than N-doped CDs, the efficiency of producing O-1(2) was 27%, and the photothermal conversion efficiency reached 34.4%. The study provides new insight into the synthesis of carbon-based nanodrugs for synergistic phototherapy and accurate diagnosis of tumors.
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