Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 24, Pages 27895-27903Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c05705
Keywords
pH reversible activation; photothermal/photodynamic-in-one probe; NIR fluorescence imaging; charge reversal-targeting; precision sterilization
Funding
- National Natural Science Foundation of China [21934002, 21804056, 21804057]
- Natural Science Foundation of Jiangsu Province, China [BK20180581, BK20180584]
- China Postdoctoral Science Foundation [2018 M630511]
- Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province
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The study presents a smart nanoplatform with synergistic chemo-phototherapy function for targeted imaging and efficient sterilization of bacteria, with minimal side effects on normal tissues.
Phototherapy holds great promise in the treatment of bacterial infections, especially the multidrug resistant bacterial infections. However, most therapeutic agents are based on the integration of individual photothermal agents and photosensitizers, always in the activated state, and generally lack bacterial specificity, resulting in uncertain pharmacokinetics and serious nonspecific damage to normal tissues. Herein, we report a pH-responsive nanoplatform with synergistic chemo-phototherapy function for smart fluorescence imaging-guided precision sterilization. pH reversible activated symmetric cyanine was designed and prepared as a bacterial-specific imaging unit and PTT/PDT-in-one agent. Meanwhile, a guanidinium-based covalent organic framework (COF) was employed as a nanocarrier and chemotherapy agent to build the intelligent nanoplatform via electrostatic self-assembly. The self-assembly of the PTT/PDT-in-one agent and the COF greatly improves the stability and blood circulation of the PTT/PDT-in-one agent and provides charge-reversed intelligent targeting ability. The developed smart nanoplatform not only enables bacterial-targeted imaging but also possesses chemo/PTT/PDT synergetic high-efficiency bactericidal effects with little side effects, showing great potential in practical applications.
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